New amide bond ligation method described in JACS
Arun Shivalingam, Agnes Tyburn and Afaf El-Sagheer’s paper Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation, which describes an exciting new amide bond ligation method for DNA that is chemically orthogonal to CuAAC “click” ligation, has been published online in J. Amer. Chem. Soc..
Poster prize for Arun Shivalingam
Arun Shivalingam has won the ChemGenes-sponsored Poster Prize at the 14th RSC Nucleic Acids Forum held in London on the 6th of July (www.rsc.org/events/detail/31569/the-14th-nucleic-acids-forum). The forum aims to bring together researchers at interface of chemistry and biology with a particular focus on nucleic acids. Arun’s work describes the design and refinement of artificial nucleic acid backbones that can be formed by chemical ligation and allow faithful replication of the information encoded.