5-Formylcytosine shown not to change the global structure of DNA
In a paper published in Nat. Struct. Mol. Biol., we have shown that, contrary to previous observations, 5-formylcytosine does not significantly alter DNA structure
New amide bond ligation method described in JACS
Arun Shivalingam, Agnes Tyburn and Afaf El-Sagheer’s paper Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation, which describes an exciting new amide bond ligation method for DNA that is chemically orthogonal to CuAAC “click” ligation, has been published online in J. Amer. Chem. Soc..