Tom Brown Group

Enzymatic Incorporation and Fluorescent Labelling of Cyclooctyne-Modified Deoxyuridine Triphosphates in DNA

X. Ren, M. Gerowska, A. H. El-Sagheer and T. Brown. Bioorg. Med. Chem. 2014.

Reverse transcription through a bulky triazole linkage in RNA: implications for RNA sequencing

X. Chen, A. H. El-Sagheer and T. Brown. Chem. Commun. 50, 7597-7600, 2014.

Force-induced melting of DNA—evidence for peeling and internal melting from force spectra on short synthetic duplex sequences

N. Bosaeus, A. H. El-Sagheer, T. Brown, B. Akerman and B. Norden. Nucleic Acids Res. 42 (12), 8083-8091, 2014.

A Mutant of Uracil DNA Glycosylase That Distinguishes between Cytosine and 5-Methylcytosine

S. T. Kimber, T. Brown and K. R. Fox. PLOS ONE 2014.

Functionalizing Designer DNA Crystals with a Triple-Helical Veneer

D. A. Rusling, A. R. Chandrasekaran, Y. P. Ohayon, T. Brown, K. R. Fox, R. Sha, C. Mao, N. C. Seeman. Angew. Chem. Int. Ed. 53 (15), 3979-3982, 2014.

Transcription of Click-Linked DNA in Human Cells

C. N. Birts, A. P. Sanzone, A. H. El-Sagheer, J. P. Blaydes, T. Brown and A. Tavassoli. Angew. Chem. Int. Ed. 53 (9), 2362-2365, 2014.

Self-reporting hybridisation assay for miRNA analysis

J. Riley, T. Brown, N. Gale, J. Herniman and G. J. Langley. Analyst 139, 1088-1092, 2014.

Structural insights into how 5-hydroxymethylation influences transcription factor binding

L. Lercher, M. A. McDonough, A. H. El-Sagheer, A. Thalhammer, S. Kriaucionis, T. Brown and C. J. Schofield. Chem. Commun. 50, 1794-1796, 2014.

Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility

A. H. El-Sagheer and T. Brown. Chem. Sci. 5, 253-259, 2014.

Triplex-mediated analysis of cytosine methylation at CpA sites in DNA

M. W. Johannsen, S. R. Gerrard, T. Melvin and T. Brown. Chem. Commun. 50, 551-553, 2014.

Measurement of a Reaction-Diffusion Crossover in Exciton-Exciton Recombination inside Carbon Nanotubes Using Femtosecond Optical Absorption

J. Allam, M. T. Sajjad, R. Sutton, K. Litvinenko, Z. Wang, S. Siddique, Q.-H. Yang, W. H. Loh and T. Brown. Phys. Rev. Lett. 111, 197401, 2013.

Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing

A. Heuer-Jungemann, P. K. Harimech, T. Brown and A. G. Kanaras. Nanoscale 5, 9503-9510, 2013.

Copper-free click chemistry as an emerging tool for the programmed ligation of DNA-functionalised gold nanoparticles

A. Heuer-Jungemann, R. Kirkwood, A. H. El-Sagheer, T. Brown and A. G. Kanaras. Nanoscale 2013.

Solid phase click ligation for the synthesis of very long oligonucleotides

J. Qiu, A. H. El-Sagheer and T. Brown. Chem. Commun. 49, 6959-6961, 2013.

The Structure of FemXWv in Complex with a Peptidyl-RNA Conjugate: Mechanism of Aminoacyl Transfer from Ala-tRNAAla to Peptidoglycan Precursors

M. Fonvielle, I. Li de La Sierra-Gallay, A. H. El-Sagheer, M. Lecerf, D. Patin, D. Mellal, C. Mayer, D. Blanot, N. Gale, T. Brown, H. van Tilbeurgh, M. Ethève-Quelquejeu and M. Arthur. Angew. Chem. Int. Ed. 52 (28), 7278-7281, 2013.

Use of a large Stokes-shift fluorophore to increase the multiplexing capacity of a point-of-care DNA diagnostic device

J. A. Richardson, T. Morgan, M. Andreou and T. Brown. Analyst 138, 3626-3628, 2013.

Initial DNA Interactions of the Binuclear Threading Intercalator ?,?-[?-bidppz(bipy)4Ru2]4+: An NMR Study with [d(CGCGAATTCGCG)]2

L. Wu, A. Reymer, C. Persson, K. Kazimierczuk, T. Brown, P. Lincoln, B. Norden and M. Billeter. Chem. Eur. J. 19 (17), 5401-5410, 2013.

Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers

J. A. Milton, S. Patole, H. Yin, Q. Xiao, T. Brown and T. Melvin. Nucleic Acids Res. 41 (7), 80, 2013.

Denaturation of dsDNA Immobilised at a Negatively Charged Gold Electrode is not caused by Electrostatic Repulsion

R. P. Johnson, N. Gale, J. A. Richardson, T. Brown and P. N. Bartlett. Chem. Sci. 4, 1625-1632, 2013.

Non-covalent Single Transcription Factor Encapsulation Inside a DNA Cage

R. Crawford, C. M. Erben, J. Periz, L. M. Hall, T. Brown, A. J. Turberfield and A. N. Kapanidis. Angew. Chem. Int. Ed. 52 (8), 2284-2288, 2013.