Our research is interdisciplinary, focusing on nucleic acid chemistry and its applications in other fields including DNA diagnostics, forensic science and nanotechnology.
Over 300 research papers and patents
Our publications have been cited more than 13000 times.
Our research has led to the foundation of three companies, as well as the development of several new technologies in collaboration with industrial partners.
New amide bond ligation method described in JACS
Arun Shivalingam, Agnes Tyburn and Afaf El-Sagheer’s paper Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation, which describes an exciting new amide bond ligation method for DNA that is chemically orthogonal to CuAAC “click” ligation, has been published online in J. Amer. Chem. Soc..
Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation
2017.J. Am. Chem. Soc.