Paper on 2'-Substituted 2-amino-3-methylpyridine ribonucleosides published in MedChemComm
Apr 20th 2011, 08:28
A paper on 2’-Substituted 2-amino-3-methylpyridine ribonucleosides in triplex-forming oligonucleotides has been published in MedChemComm.
The paper describes a new synthesis of the phosphoramidite monomers of 2-amino-3-methyl-5-(2’-O-methyl-beta-D-ribofuranosyl)pyridine (Me-MAP) and its 2-O-methoxyethyl analogue (MOE-MAP). The incorporation of Me-MAP or MOE-MAP into triplex-forming oligonucleotides (TFOs) makes them more resistant to degradation by serum nucleases than dMAP and dC, which is potentially important for in vivo applications.