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Transient DNA binding to gapped DNA substrates links DNA sequence to the single-molecule kinetics of protein-DNA interactions

Rebecca Andrews, Horst Steuer, Afaf H El-Sagheer, Abhishek Mazumder, Hafez el Sayyed, Arun Shivalingam, Tom Brown, Achillefs N Kapanidis. bioRxiv 0 (0), 2022.

The role of chemistry in the success of oligonucleotides as therapeutics

Pawan Kumar and Tom Brown. Beilstein Journal of Organic Chemistry 18, 197-199, 2022.

“Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates

Bahareh Amirloo, Yaroslav Staroseletz, Sameen Yousaf, David J Clarke, Tom Brown, Harmesh Aojula, Marina A Zenkova, Elena V Bichenkova. Nucleic Acids Res. 50 (2), 651-673, 2022.

Chirality transmission in macromolecular domains

Shankar Pandey, Shankar Mandal, Mathias Bogetoft Danielsen, Asha Brown, Changpeng Hu, Niels Johan Christensen, Alina Vitaliyivna Kulakova, Shixi Song, Tom Brown, Knud J. Jensen, Jesper Wengel, Chenguang Lou & Hanbin Mao . Nature Communications 13, 76, 2022.

An Investigation into the Resistance of Spherical Nucleic Acids against DNA Enzymatic Degradation

Maria-Eleni Kyriazi, Afaf H. El-Sagheer, Igor L. Medintz, Tom Brown, and Antonios G. Kanaras*. Bioconjugate Chem. 33 (1), 219-225, 2022.

Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers

Cheng Jin, A. H. EI-Sagheer, Siqi Li, Katherine A. Vallis, Weihong Tan, Tom Brown. Angew. Chem. Int. Ed. e202114016 1, 2022.

Deoxyribonucleic Acid Encoded and Size-Defined pi-Stacking of Perylene Diimides

Jeffrey Gorman, Sarah R. E. Orsborne, Akshay Sridhar, Raj Pandya, Peter Budden, Alexander Ohmann, Naitik A. Panjwani, Yun Liu, Jake L. Greenfield, Simon Dowland, Victor Gray, Seán T. J. Ryan, Sara De Ornellas, Afaf H. El-Sagheer, Tom Brown, Jonathan R. Nitschke, Jan Behrends, Ulrich F. Keyser, Akshay Rao, Rosana Collepardo-Guevara, Eugen Stulz, Richard H. Friend*, and Florian Auras*. Journal of the American Chemical Society 144 (1), 368-376, 2022.

Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly

Angela F. De Fazio, Doxi Misatziou, Ysobel R. Baker, Otto L. Muskens, Tom Brown and Antonios G. Kanaras. Chemical Society Reviews 50, 13410-13440, 2021.

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors

Shifali Shishodia, Marina Demetriades, Dong Zhang, Nok Yin Tam, Pratheesh Maheswaran, Caitlin Clunie-O’Connor, Anthony Tumber, Ivanhoe K. H. Leung, Yi Min Ng, Thomas M. Leissing, Afaf H. El-Sagheer, Eidarus Salah, Tom Brown, Wei Shen Aik*, Michael A. McDonough*, and Christopher J. Schofield*. Journal of Medical Chemistry 64 (22), 16609-16625, 2021.

A Click Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II)-Modified Triplex-Forming Oligonucleotides

Joseph Hennessy, Bríonna McGorman, Zara Molphy, Nicholas P. Farrell, Daniel Singleton, Tom Brown, Andrew Kellett. Angew. Chem. Int. Ed. 61 (3), 2022.

A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility

Sven Epple, Aman Modi, Ysobel R. Baker, Ewa Wegrzyn, Diallo Traoré, Przemyslaw Wanat, Agnes E. S. Tyburn, Arun Shivalingam, Lapatrada Taemaitree, Afaf H. El-Sagheer, and Tom Brown*. Journal of the American Chemical Society 143 (39), 16293-16301, 2021.

Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification

Ysobel R Baker, Liyiwen Yuan, Jinfeng Chen, Roman Belle, Robert Carlisle, Afaf H El-Sagheer, Tom Brown. Nucleic Acids Res. 49 (16), 9042-9052, 2021.

Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology

Sven Epple, Afaf H. El-Sagheer, Tom Brown. Energing topics in life science 5 (5), 691-697, 2021.

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

Martin Philpott, Jonathan Watson, Anjan Thakurta, Tom Brown Jr, Tom Brown Sr, Udo Oppermann & Adam P. Cribbs. Nature Biotechnology 39, 1517-1520, 2021.

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

Philpott M, Watson J, Thakurta A, Brown T, Brown T, Oppermann U, Cribbs AP. Nature Biotechnology 39 (12), 1517-1520, 2021.

DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second

Alisina Bazrafshan, Maria-Eleni Kyriazi, Brandon Alexander Holt, Wenxiao Deng, Selma Piranej, Hanquan Su, Yuesong Hu, Afaf H. El-Sagheer, Tom Brown, Gabriel A. Kwong, Antonios G. Kanaras, and Khalid Salaita*. ACS Nano 15 (5), 8427-8438, 2021.

Mismatch detection in homologous strand exchange amplified by hydrophobic effects

Bengt Nordén, Tom Brown, Bobo Feng. Biopolymers 112 (4), 2021.

Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids

Miguel Xavier, Maria-Eleni Kyriazi, Stuart Lanham, Konstantina Alexaki, Elloise Matthews, Afaf H. El-Sagheer, Tom Brown, Antonios G. Kanaras*, and Richard O. C. Oreffo*. ACS Nano 15 (4), 6909-6916, 2021.

INSIGHT: A population-scale COVID-19 testing strategy combining point-of-care diagnosis with centralized high-throughput sequencing

Qianxin Wu, Chengqu Suo, Tom Brown, Tengyao Wang, Sarah A. Teichmann, Andrew R. Bassett. Science advances 7 (7), 2021.

DNA-Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology

Nicolò Zuin Fantoni, Tom Brown, Andrew Kellett. ChemBioChem 22 (13), 2184-2205, 2021.

Showing papers 1-20 of 422 total (Page 1 of 22)

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