Tom Brown Group

Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

S. Walsh, A. H. El-Sagheer and T. Brown. Chem. Sci. 9, 7681-7687, 2018.

Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size

Y. R. Baker, J. Chen, J. Brown, A. H. El-Sagheer, P. Wiseman, E. Johnson, P. Goddard and T. Brown. Nucleic Acids Res. 46 (15), 7495-7505, 2018.

Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

P. Kumar, L. Truong Y. R. Baker, A. H. El-Sagheer and T. Brown. ACS Omega 3 (6), 6976-6987, 2018.

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading

R. Amunugama, S. Willcox, R. A. Wu, U. B. Abdullah, A. H. El-Sagheer, T. Brown, P. J. McHugh, J. D. Griffith and J. C. Walter. Cell Reports 23, 3419-3428, 2018.

Synthesis of Lipid-Carbohydrate-Peptidyl-RNA Conjugates to Explore the Limits Imposed by the Substrate Specificity of Cell Wall Enzymes on the Acquisition of Drug Resistance

M. Fonvielle, A. Bouhss, C. Hoareau, D. Patin, D. Mengin-Lecreulx, L. Iannazzo, N. Sakkas, A. H. El-Sagheer, T. Brown, M. Etheve-Quelquejeu and M. Arthur. Chem. Eur. J. 24 (56), 14911-14915, 2018.

Graphene Oxide-Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops

D. Giust, M. I. Lucio, A. H. El-Sagheer, T. Brown, L. E. Williams, O. L. Muskens and A. G. Kanaras. ACS Nano 12 (6), 6273-6279, 2018.

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases

S. Shishodia, D. Zhang, A. H. El-Sagheer, T. Brown, T. D. W. Claridge, C. J. Schofield and R. J. Hopkinson. Org. Biomol. Chem. 16 (21), 4021-4032, 2018.

Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures

I. Manuguerra, S. Croce, A. H. El-Sagheer, A. Krissanaprasit, T. Brown, K. V. Gothelf and A. Manetto. Chem. Commun. 54, 4529-4532, 2018.

Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers

M. Kyriazi, D. Giust, A. H. El-Sagheer, P. M. Lackie, O. L. Muskens, T. Brown and A. G. Kanaras. ACS Nano 2018.

DNA Recognition by Parallel Triplex Formation

Keith R. Fox, Tom Brown and David A. Rusling. DNA-targeting Molecules as Therapeutic Agents 1-32, 2018.

Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue

M. Bood, A. F. Fuchtbauer, M. S. Wranne, J. J. Ro, S. Sarangamath, A. H. El-Sagheer, D. L. M. Rupert, R. S. Fisher, S. W. Magennis, A. C. Jones, F. Hook, T. Brown, B. H. Kim, A. Dahleni, L. M. Wilhelmsson and M. Grotli. Chem. Sci. 2018.

Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

Johanna Midelet, Afaf H. El-Sagheer, Tom Brown, Antonios G. Kanaras, Anne Débarre, Martinus H. V. Werts. ChemPhysChem 19 (7), 827-836, 2018.

Sensing of Vimentin mRNA in 2D and 3D Models of Wounded Skin Using DNA-Coated Gold Nanoparticles

P. Vilela, A. Heuer-Jungemann, A. H. El-Sagheer, T. Brown, O. L. Muskens, N. R. Smyth and A. G. Kanaras. Small 2018.

Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination.

C. Slator, Z. Molphy, V. McKee, C. Long, T. Brown and A. Kellett. Nucleic Acids Res. 46 (6), 2733-2750, 2018.

Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

J. Piccoli, R. Hein, A. H. El-Sagheer, T. Brown, E. M. Cilli, P. R. Bueno and J. J. Davis. Anal. Chem. 90 (5), 3005-3008, 2018.

Short-Read Single-Molecule DNA Sequencing for Highly Parallel Analysis of Protein-DNA Interactions

Rebecca Andrews, Horst Steuer, Arun Shivalingam, Afaf H. El-Sagheer, Tom Brown, Achillefs N. Kapanidis. Biophysical Journal 114 (3), 2018.

Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA

J. S. Hardwick, A. N. Lane and T. Brown. BioEssays 40 (3), 2018.

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

S. Matysiak, K. Hellmuth, A. H. El-Sagheer, A. Shivalingam, Y. Ariyurek, M. de Jong, M. J. Hollestelle, R. Out and T. Brown. Org. Biomol. Chem. 16, 48-52, 2018.

Single tube gene synthesis by phosphoramidate chemical ligation

A. H. El-Sagheer and T. Brown. Chem. Commun. 53, 10700-10702, 2017.

Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation

M. Kukwikila, N. Gale, A. H. El-Sagheer, T. Brown and A. Tavassoli. Nat. Chem. 9, 1089-1098, 2017.