Tom Brown Group

Nucleic Acids Research

New paper in PNAS

Sep 14th 2012, 09:52

A paper published in PNAS, in collaboration with Bengt Nordén, Steven B. Smith and Carlos Bustamante uses optical tweezers and click-linked duplexes to prove for the first time the existence of a stretched base-paired form of DNA.

Tension induces a base-paired overstretched DNA conformation

N. Bosaeus, A. H. El-Sagheer, T. Brown, S. B. Smith, B. Akerman, C. Bustamante and B. Norden. Proc. Natl. Acad. Sci. U.S.A. 109 (38), 15179-15184, 2012.