An analogue of adenine that forms an A.T base pair of comparable stability to G.C

J. Booth, W. J. Cummins and T. Brown. Chem. Commun. 2208-2209, 2004.

Abstract

The heterocyclic base 7-aminopropargyl-7-deaza-2,6-diaminopurine (D) has been incorporated into oligodeoxynucleotides. D:T has similar thermodynamic stability to G:C and is a stable analogue of A:T.

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