CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo 2,3-d pyrimidin-2(7H)-one nucleoside analogues

S. R. Gerrard, N. Srinivasan, K. R. Fox and T. Brown. Nucleosides Nucleotides Nucl. Acids 26 (10-12), 1363-1367, 2007.


Triplex-mediated recognition of Py.Pu base pairs in DNA is a greater challenge than for Pu.Py base pairs as fewer hydrogen bonds are presented for binding in the major groove. Initial studies on m-aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7 H)-one suggest that selective recognition of the CG base pair is possible.