Synthesis of anthraquinone oligonucleotides for triplex stabilization
Nucleosides Nucleotides Nucl. Acids 26 (8-9), 921-925, 2007.
Abstract
The synthesis of two anthraquinone phosphoramidites is described. In both cases the anthraquinone moiety is attached via a linker to the 5-position of a uracil base, allowing incorporation at any thymidine position in an oligonucleotide sequence. Anthraquinone-modified oligonucleotides have potential applications as triplex stabilizers and fluorescence quenchers.