Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained

A. Dallmann, A. H. El-Sagheer, L. Dehmel, C. Muegge, C. Griesinger, N. P. Ernsting and T. Brown. Chem. Eur. J. 17 (52), 14714-14717, 2011.

Abstract

A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen. The results explain the surprising biocompatibility of triazole-linked DNA.

View paper

Latest paper

Modular and Automated Synthesis of Oligonucleotide-Small Molecule Conjugates for Cathepsin B Mediated Traceless Release of Payloads

May 30th, 2024

Cheng Jin, Siqi Li, Katherine A. Vallis, Afaf H. El-Sagheer and Tom Brown. RSC Chemical Biology