Triplex-Directed Covalent Cross-Linking of a DNA Nanostructure

D. A. Rusling, I. Nandhakumar, T. Brown and K. R. Fox. Chem. Commun. 48, 9592-9594, 2012.


The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.