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An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA

L. Taemaitree, A. Shivalingam, A. H. El-Sagheer and T. Brown. Nat. Commun. 10, 2019.

Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation

M. Kukwikila, N. Gale, A. H. El-Sagheer, T. Brown and A. Tavassoli. Nat. Chem. 9, 1089-1098, 2017.

5-Formylcytosine does not change the global structure of DNA

J. S. Hardwick, D. Ptchelkine, A. H. El-Sagheer, I. Tear, D. Singleton, S. E. V. Phillips, A. N. Lane and T. Brown. Nat. Struct. Mol. Biol. 24, 544-552, 2017.

Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation

A. Shivalingam, A. E. S. Tyburn, A. H. El-Sagheer and T. Brown. J. Am. Chem. Soc. 139 (4), 1575-1583, 2017.

2'-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA

M. M. Haugland, A. H. El-Sagheer, R. J. Porter, J. Pena, T. Brown, E. A. Anderson and J. E. Lovett. J. Am. Chem. Soc. 2016.

An autonomous molecular assembler for programmable chemical synthesis

W. Meng, R. A. Muscat, M. L. McKee, P. J. Milnes, A. H. El-Sagheer, J. Bath, B. G. Davis, T. Brown, R. K. O'Reilly and A. J. Turberfield. Nat. Chem. 2016.

Reversible Ligation of Programmed DNA-Gold Nanoparticle Assemblies

P. K. Harimech, S. R. Gerrard, A. H. El-Sagheer, T. Brown and A. G. Kanaras. J. Am. Chem. Soc. 137 (29), 9242-9245, 2015.

Transcription of Click-Linked DNA in Human Cells

C. N. Birts, A. P. Sanzone, A. H. El-Sagheer, J. P. Blaydes, T. Brown and A. Tavassoli. Angew. Chem. Int. Ed. 53 (9), 2362-2365, 2014.

Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility

A. H. El-Sagheer and T. Brown. Chem. Sci. 5, 253-259, 2014.

Click Nucleic Acid Ligation: Applications in Biology and Nanotechnology

A. H. El-Sagheer and T. Brown. Acc. Chem. Res. 45 (8), 1258-1267, 2012.

Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained

A. Dallmann, A. H. El-Sagheer, L. Dehmel, C. Muegge, C. Griesinger, N. P. Ernsting and T. Brown. Chem. Eur. J. 17 (52), 14714-14717, 2011.

Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template

A. H. El-Sagheer and T. Brown. Chem. Commun. 47 (44), 12057-12058, 2011.

Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli

A. H. El-Sagheer, A. P. Sanzone, R. Gao, A. Tavassoli and T. Brown. Proc. Natl. Acad. Sci. U.S.A. 108 (28), 11338-11343, 2011.

New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes

A. H. El-Sagheer and T. Brown. Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15329-15334, 2010.

Click chemistry with DNA

A. H. El-Sagheer and T. Brown. Chem. Soc. Rev. 39 (4), 1388-1405, 2010.

High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler

R. A. J. Darby, M. Sollogoub, C. M. McKeen, L. Brown, A. Risitano, N. Brown, C. Barton, T. Brown and K. R. Fox. Nucleic Acids Res. 30 (9), e39, 2002.

Structure of an adenine-cytosine base pair in DNA and its implications for mismatch repair

W. N. Hunter, T. Brown, N. N. Anand and O. Kennard. Nature 320 (6062), 552-555, 1986.

Synthesis and Polymerase Chain Reaction Amplification of DNA Strands Containing an Unnatural Triazole Linkage

A. H. El-Sagheer and T. Brown. J. Am. Chem. Soc. 131 (11), 3958-3964, 2009.

DNA Polymorphism as an Origin of Adenine-Thymine Tract Length-Dependent Threading Intercalation Rate

P. Nordell, F. Westerlund, A. Reymer, A. H. El-Sagheer, T. Brown, B. Norden and P. Lincoln. J. Am. Chem. Soc. 130 (44), 14651-14658, 2008.

SERS-Melting: A New Method for Discriminating Mutations in DNA Sequences

S. Mahajan, J. A. Richardson, T. Brown and P. N. Bartlett. J. Am. Chem. Soc. 130 (46), 15589-15601, 2008.

Showing papers 1-20 of 33 total (Page 1 of 2)

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