Tom Brown Group

DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals

M. Moros, M. Kyriazi, A. H. El-Sagheer, T. Brown, C. Tortiglione and A. G. Kanaras. ACS Appl. Mater. Interfaces 11 (15), 13905-13911, 2018.

Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A

E. Dürr, W. Doherty, S. Y. Lee, A. H. El-Sagheer, A. Shivalingam, P. J. McHugh, T. Brown and J. F. McGouran. ChemistrySelect 3 (45), 12824-12829, 2018.

Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue

C. P. Lawson, A. F. Fuchtbauer, M. S. Wranne, T. Giraud, T. Floyd, B. Dumat, N. K. Andersen, A. H. El-Sagheer, T. Brown, H. Graden, L. M. Wilhelmsson and M. Grotli. Sci. Rep. 8, 2018.

Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation

J. Chen, Y. R. Baker, A. Brown, A. H. El-Sagheer and T. Brown. Chem. Sci. 9, 8110-8120, 2018.

Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

S. Walsh, A. H. El-Sagheer and T. Brown. Chem. Sci. 9, 7681-7687, 2018.

Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size

Y. R. Baker, J. Chen, J. Brown, A. H. El-Sagheer, P. Wiseman, E. Johnson, P. Goddard and T. Brown. Nucleic Acids Res. 46 (15), 7495-7505, 2018.

Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

P. Kumar, L. Truong Y. R. Baker, A. H. El-Sagheer and T. Brown. ACS Omega 3 (6), 6976-6987, 2018.

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading

R. Amunugama, S. Willcox, R. A. Wu, U. B. Abdullah, A. H. El-Sagheer, T. Brown, P. J. McHugh, J. D. Griffith and J. C. Walter. Cell Reports 23, 3419-3428, 2018.

Synthesis of Lipid-Carbohydrate-Peptidyl-RNA Conjugates to Explore the Limits Imposed by the Substrate Specificity of Cell Wall Enzymes on the Acquisition of Drug Resistance

M. Fonvielle, A. Bouhss, C. Hoareau, D. Patin, D. Mengin-Lecreulx, L. Iannazzo, N. Sakkas, A. H. El-Sagheer, T. Brown, M. Etheve-Quelquejeu and M. Arthur. Chem. Eur. J. 24 (56), 14911-14915, 2018.

Graphene Oxide-Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops

D. Giust, M. I. Lucio, A. H. El-Sagheer, T. Brown, L. E. Williams, O. L. Muskens and A. G. Kanaras. ACS Nano 12 (6), 6273-6279, 2018.

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases

S. Shishodia, D. Zhang, A. H. El-Sagheer, T. Brown, T. D. W. Claridge, C. J. Schofield and R. J. Hopkinson. Org. Biomol. Chem. 16 (21), 4021-4032, 2018.

Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures

I. Manuguerra, S. Croce, A. H. El-Sagheer, A. Krissanaprasit, T. Brown, K. V. Gothelf and A. Manetto. Chem. Commun. 54, 4529-4532, 2018.

Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers

M. Kyriazi, D. Giust, A. H. El-Sagheer, P. M. Lackie, O. L. Muskens, T. Brown and A. G. Kanaras. ACS Nano 2018.

DNA Recognition by Parallel Triplex Formation

Keith R. Fox, Tom Brown and David A. Rusling. DNA-targeting Molecules as Therapeutic Agents 1-32, 2018.

Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue

M. Bood, A. F. Fuchtbauer, M. S. Wranne, J. J. Ro, S. Sarangamath, A. H. El-Sagheer, D. L. M. Rupert, R. S. Fisher, S. W. Magennis, A. C. Jones, F. Hook, T. Brown, B. H. Kim, A. Dahleni, L. M. Wilhelmsson and M. Grotli. Chem. Sci. 2018.

Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

Johanna Midelet, Afaf H. El-Sagheer, Tom Brown, Antonios G. Kanaras, Anne Débarre, Martinus H. V. Werts. ChemPhysChem 19 (7), 827-836, 2018.

Sensing of Vimentin mRNA in 2D and 3D Models of Wounded Skin Using DNA-Coated Gold Nanoparticles

P. Vilela, A. Heuer-Jungemann, A. H. El-Sagheer, T. Brown, O. L. Muskens, N. R. Smyth and A. G. Kanaras. Small 2018.

Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination.

C. Slator, Z. Molphy, V. McKee, C. Long, T. Brown and A. Kellett. Nucleic Acids Res. 46 (6), 2733-2750, 2018.

Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

J. Piccoli, R. Hein, A. H. El-Sagheer, T. Brown, E. M. Cilli, P. R. Bueno and J. J. Davis. Anal. Chem. 90 (5), 3005-3008, 2018.

Short-Read Single-Molecule DNA Sequencing for Highly Parallel Analysis of Protein-DNA Interactions

Rebecca Andrews, Horst Steuer, Arun Shivalingam, Afaf H. El-Sagheer, Tom Brown, Achillefs N. Kapanidis. Biophysical Journal 114 (3), 2018.