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Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors

P. J. McHugh, A. M. Thomas, S. Brolih, J. F. McGouran, A. H. El-Sagheer, D. Ptchelkine, M. Jones and T. Brown. Chem. Commun. 2019.

Radiolabeled oligonucleotides targeting the RNA subunit of telomerase inhibit telomerase and induce DNA damage in telomerase-positive cancer cells

M. R. Jackson, B. M. Bavelaar, P. A. Waghorn, M. R. Gill, A. H. El-Sagheer, T. Brown, M. Tarsounas and K. A. Vallis. Cancer Res. 2019.

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting

P. Klimkowski, S. De Ornellas, D. Singleton, A. H. El-Sagheer and T. Brown. Org. Biomol. Chem. 17, 5943-5950, 2019.

Curtailing their negativity

A. Brown and T. Brown. Nat. Chem. 11 (6), 501-503, 2019.

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications

C. Thorpe, S. Epple, B. Woods, A. H. El-Sagheer and T. Brown. Org. Biomol. Chem. 17, 5341-5348, 2019.

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA

L. Taemaitree, A. Shivalingam, A. H. El-Sagheer and T. Brown. Nat. Commun. 10, 2019.

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

W. Doherty, E. Dürr, H. T. Baddock, S. Y. L, P. J. McHugh, T. Brown, M. O. Senge, E. M. Scanlana and J. F. McGouran. Org. Biomol. Chem. 2019.

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