Tom Brown Group

Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates

Yaroslav Staroseletz, Bahareh Amirloo, Aled Williams, Alexander Lomzov, Kepa K Burusco, David J Clarke, Tom Brown, Marina A Zenkova, Elena V Bichenkova. Nucleic Acids Res. 48 (19), 10662-10679, 2020.

An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells

Martin R. Gill, Michael G. Walker, Sarah Able, Ole Tietz, Abirami Lakshminarayanan, Rachel Anderson, Rod Chalk, Afaf H. El-Sagheer, Tom Brown, Jim A. Thomas and Katherine A. Vallis. Chemical Science 11, 8936-8944, 2020.

Development of Gene-Targeted Polypyridyl Triplex-Forming Oligonucleotide Hybrids

Nicolò Zuin Fantoni, Bríonna McGorman, Zara Molphy, Daniel Singleton, Sarah Walsh, Afaf H. El-Sagheer, Vickie McKee, Tom Brown, Andrew Kellett. ChemBioChem 21 (24), 3563-3574, 2020.

Melting temperature measurement and mesoscopic evaluation of single, double and triple DNA mismatches

Luciana M. Oliveira, Adam S. Long, Tom Brown, Keith R. Fox and Gerald Weber. Chemical Science 11, 8273-8287, 2020.

Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor

Anna Wypijewska del Nogal, Anders F Füchtbauer, Mattias Bood, Jesper R Nilsson, Moa S Wranne, Sangamesh Sarangamath, Pauline Pfeiffer, Vinoth Sundar Rajan, Afaf H El-Sagheer, Anders Dahlén, Tom Brown, Morten Grøtli, L Marcus Wilhelmsson. Nucleic Acids Res. 48 (14), 7640-7652, 2020.

Dynamics of the 4D genome during in vivo lineage specification and differentiation

A. Marieke Oudelaar, Robert A. Beagrie, Matthew Gosden, Sara de Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf H. El-Sagheer, Jelena M. Telenius, Tom Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs & Jim R. Hughes . Nature Communications 11, 2722, 2020.

Direct Detection and Discrimination of Nucleotide Polymorphisms Using Anthraquinone Labeled DNA Probes

Sarah A. Goodchild, Rachel Gao, Daniel P. Shenton, Alastair J. S. McIntosh, Tom Brown and Philip N. Bartlett*. Frontiers in Chemistry 8, 381, 2020.

Advances and challenges in epigenomic single-cell sequencing applications

Martin Philpott, Adam P. Cribbs, TomBrown Jr, Tom Brown Sr, Udo Oppermann. Current Opinion in Chemical Biology 57, 17-26, 2020.

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

Sven Epple, Cameron Thorpe, Ysobel R. Baker, Afaf H. El-Sagheer, Tom Brown. Chemical Communications 56, 5496-5499, 2020.

Shining Light on CRISPR Gene Editing

Lapatrada Taemaitree and Tom Brown. ACS central science 6 (5), 616-618, 2020.

Molecular flexibility of DNA as a key determinant of RAD51 recruitment

Federico Paoletti, Afaf H El-Sagheer, Jun Allard, Tom Brown, Omer Dushek, Fumiko Esashi. The EMBO Journal 39 (7), 2020.

Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly

Arun Shivalingam, Lapatrada Taemaitree, Afaf H. El-Sagheer, Tom Brown. Angew. Chem. Int. Ed. 59 (28), 11416-11422, 2020.

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

Jack S Hardwick, Marius M Haugland, Afaf H El-Sagheer, Denis Ptchelkine, Frank R Beierlein, Andrew N Lane, Tom Brown, Janet E Lovett, Edward A Anderson. Nucleic Acids Res. 48 (6), 2830-2840, 2020.

Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4

Anders F. Füchtbauer, Moa S. Wranne, Sangamesh Sarangamath, Mattias Bood, Afaf H. El-Sagheer, Tom Brown, Henrik Gradén, Morten Grøtli, L. Marcus Wilhelmsson. ChemPlusChem 85 (2), 319-326, 2020.

DNA Structural Changes Induced by Intermolecular Triple Helix Formation

Ibrahim Sayoh, David A. Rusling, Tom Brown, Keith R. Fox*. ACS Omega 5 (3), 1679-1687, 2020.

Searching for the ideal triazole: Investigating the 1,5-triazole as a charge neutral DNA backbone mimic

Ysobel R. Baker, Diallo Traoré, Przemyslaw Wanat, Agnès Tyburn, Afaf H. El-Sagheer, TomBrown. Tetrahedron 76 (7), 130914, 2020.

Oxidative DNA Cleavage with Clip-Phenanthroline Triplex-Forming Oligonucleotide Hybrids

Alessandro Panattoni, Afaf H. El-Sagheer, Tom Brown, Andrew Kellett, Michal Hocek. ChemBioChem 21, 991-1000, 2020.

Stability of the different arms of a DNA tetrahedron and its interaction with a minor groove ligand

Michael L.J. Carter, David A. Rusling, Steven Gurr, Tom Brown, Keith R. Fox. Biophysical Chemistry 25, 106270, 2020.