Nucleic acid structure

Three-dimensional image showing DNA binding and nucleotide flipping by the human DNA repair protein AGT. In the early part of my academic career I used state of the art NMR and X-ray crystallography to study the properties of base pair mismatches in DNA and their implications for DNA repair. This produced a series of publications, examples of which are the elucidation of the structures of DNA duplexes containing G.T (View paper) and A.C (View paper) mispairs.