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Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications

Brionna McGorman, Nicolo Zuin Fantoni , Sinead O’Carroll , Anna Ziemele, Afaf H. El-Sagheer, Tom Brown and Andrew Kellett. Nucleic Acids Research 50, 5467-5487, 2022.

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Anna Dysko, Ysobel R. Baker, Graham McClorey, Matthew J. A. Wood, Sabine Fenner, Glynn Williams, Afaf El-Sagheer and Tom Brown. RSC Chemical Biology 3, 765-772, 2022.

Oligonucleotide analogues with locked-amide linkages have therapeutic potential

Ysobel Baker, Cameron Thorpe, Jinfeng Chen, Laura Poller, Lina Cox, Pawan Kumar, Wooi Fang Lim, Lillian Lie, Graham McClorey, Sven Epple, Daniel Singleton, Michael McDonough, Jack Hardwick, Kirsten Christensen, Matthew Wood, James Hall, Afaf El-Sagheer, Tom Brown. Research Square 0, 0, 2022.

Transient DNA binding to gapped DNA substrates links DNA sequence to the single-molecule kinetics of protein-DNA interactions

Rebecca Andrews, Horst Steuer, Afaf H El-Sagheer, Abhishek Mazumder, Hafez el Sayyed, Arun Shivalingam, Tom Brown, Achillefs N Kapanidis. bioRxiv 0 (0), 2022.

The role of chemistry in the success of oligonucleotides as therapeutics

Pawan Kumar and Tom Brown. Beilstein Journal of Organic Chemistry 18, 197-199, 2022.

“Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates

Bahareh Amirloo, Yaroslav Staroseletz, Sameen Yousaf, David J Clarke, Tom Brown, Harmesh Aojula, Marina A Zenkova, Elena V Bichenkova. Nucleic Acids Res. 50 (2), 651-673, 2022.

Chirality transmission in macromolecular domains

Shankar Pandey, Shankar Mandal, Mathias Bogetoft Danielsen, Asha Brown, Changpeng Hu, Niels Johan Christensen, Alina Vitaliyivna Kulakova, Shixi Song, Tom Brown, Knud J. Jensen, Jesper Wengel, Chenguang Lou & Hanbin Mao . Nature Communications 13, 76, 2022.

An Investigation into the Resistance of Spherical Nucleic Acids against DNA Enzymatic Degradation

Maria-Eleni Kyriazi, Afaf H. El-Sagheer, Igor L. Medintz, Tom Brown, and Antonios G. Kanaras*. Bioconjugate Chem. 33 (1), 219-225, 2022.

Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers

Cheng Jin, A. H. EI-Sagheer, Siqi Li, Katherine A. Vallis, Weihong Tan, Tom Brown. Angew. Chem. Int. Ed. e202114016 1, 2022.

Deoxyribonucleic Acid Encoded and Size-Defined pi-Stacking of Perylene Diimides

Jeffrey Gorman, Sarah R. E. Orsborne, Akshay Sridhar, Raj Pandya, Peter Budden, Alexander Ohmann, Naitik A. Panjwani, Yun Liu, Jake L. Greenfield, Simon Dowland, Victor Gray, Seán T. J. Ryan, Sara De Ornellas, Afaf H. El-Sagheer, Tom Brown, Jonathan R. Nitschke, Jan Behrends, Ulrich F. Keyser, Akshay Rao, Rosana Collepardo-Guevara, Eugen Stulz, Richard H. Friend*, and Florian Auras*. Journal of the American Chemical Society 144 (1), 368-376, 2022.

A Click Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II)-Modified Triplex-Forming Oligonucleotides

Joseph Hennessy, Bríonna McGorman, Zara Molphy, Nicholas P. Farrell, Daniel Singleton, Tom Brown, Andrew Kellett. Angew. Chem. Int. Ed. 61 (3), 2022.

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