Tom Brown Group

5-Formylcytosine does not change the global structure of DNA

J. S. Hardwick, D. Ptchelkine, A. H. El-Sagheer, I. Tear, D. Singleton, S. E. V. Phillips, A. N. Lane and T. Brown. Nat. Struct. Mol. Biol. 24, 544-552, 2017.

Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation

A. Shivalingam, A. E. S. Tyburn, A. H. El-Sagheer and T. Brown. J. Am. Chem. Soc. 139 (4), 1575-1583, 2017.

Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer’s Disease and Prostate Cancer

P. Vilela, A. H. El-Sagheer, T. M. Millar, T. Brown, O. L. Muskens and A. G. Kanaras. ACS Sensors 2 (1), 52-56, 2017.

Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes

M. Fonvielle, N. Sakkas, L. Iannazzo, C. Le Fournis, D. Patin, D. Mengin-Lecreulx, A. H. El-Sagheer, E. Braud, S. Cardon, T. Brown, M. Arthur and M. Etheve-Quelquejeu. Angew. Chem. Int. Ed. 55 (43), 13553-13557, 2016.

Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles

A. Heuer-Jungemann, A. H. El-Sagheer, P. M. Lackie, T. Brown and A. G. Kanaras. Nanoscale 8, 16857-16861, 2016.

2'-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA

M. M. Haugland, A. H. El-Sagheer, R. J. Porter, J. Pena, T. Brown, E. A. Anderson and J. E. Lovett. J. Am. Chem. Soc. 2016.

Combination probes with intercalating anchors and proximal fluorophores for DNA and RNA detection

J. Qiu, A. Wilson, A. H. El-Sagheer and T. Brown. Nucleic Acids Res. 2016.

Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking

H. O. Abdallah, Y. P. Ohayon, A. R. Chandrasekaran, R. Sha, K. R. Fox, T. Brown, D. A. Rusling, C. Maoe and N. C. Seeman. Chem. Commun. 2016.

An autonomous molecular assembler for programmable chemical synthesis

W. Meng, R. A. Muscat, M. L. McKee, P. J. Milnes, A. H. El-Sagheer, J. Bath, B. G. Davis, T. Brown, R. K. O'Reilly and A. J. Turberfield. Nat. Chem. 2016.

New two dimensional liquid-phase colorimetric assay based on old iodine-starch complexation for simple, low-cost, portable, naked-eye detection and quantification of analytes

J. Nie, T. Brown and Y. Zhang. Chem. Commun. 2016.

Stable End-Sealed DNA as Robust Nano-rulers for In Vivo Single-Molecule Fluorescence

A. Plochowietz, A. H. El-Sagheer, T. Brown and A. N. Kapanidis. Chem. Sci. 2016.

Efficient enzymatic synthesis and dual-colour fluorescent labelling of DNA probes using long chain azido-dUTP and BCN dyes

X. Ren, A. H. El-Sagheer and T. Brown. Nucleic Acids Res. 2016.

New Technologies for DNA analysis-A review of the READNA Project

S. McGinn, D. Bauer, T. Brefort, L. Dong, A. H. El-Sagheer, A. Elsharawy, G. Evans, E. Falk-Sorqvist, M. Forster, S. Fredriksson, P. Freeman, C. Freitag, J. Fritzsche, S. Gibson, M. Gullberg, M. Gut, S. Heath, I. Heath-Brun, A. J. Heron, J. Hohlbein, R. Ke, O. Lancaster, L. Le Reste, G. Maglia, R. Marie, F. Mauger, F. Mertes, M. Mignardi, L. Moens, J. Oostmeijer, R. Out, J. N. Pedersen, F. Persson, V. Picaud, D. Rotem, N. Schracke, J. Sengenes, P. F. Stahler, B. Stade, D. Stoddart, X. Teng, C. D. Veal, N. Zahra, H. Bayley, M. Beier, T. Brown, C. Dekker, B. Ekstrom, H. Flyvbjerg, A. Franke, S. Guenther, A. N. Kapanidis, J. Kaye, A. Kristensen, H. Lehrach, J. Mangion, S. Sauer, E. Schyns, J. Tost, J. M. L. M. van Helvoort, P. J. van der Zaag, J. O. Tegenfeldt, A. J. Brookes, K. Mir, M. Nilsson, S. Willcocks and I. G. Gut. N. Biotechnol. 33 (3), 311-330, 2016.

Specifically horizontally tethered DNA probes on Au surfaces allow labelled and label-free DNA detection using SERS and electrochemically driven melting

E. Papadopoulou, N. Gale, J. F. Thompson, T. A. Fleming, T. Brown and P. N. Bartlett. Chem. Sci. 7 (1), 386-393, 2016.

The effect of sequence context on the activity of cytosine DNA glycosylases

S. T. Kimber, T. Brown and K. R. Fox. Mol. Biosyst. 106, 353-358, 2015.

The effect of temperature on electrochemically driven denaturation monitored by SERS.

E. Papadopoulou, M. Meneghello, P. Marafini, R. P. Johnson, T. Brown and P. N. Bartlett. Bioelectrochemistry 106, 353-358, 2015.

Programming the assembly of gold nanoparticles on graphene oxide sheets using DNA

A. Heuer-Jungemann, L. Kiessling, E. Stratakis, E. Kymakis, A. H. El-Sagheer, T. Brown and A. G. Kanaras. J. Mater. Chem. C 3, 9379-9384, 2015.

Reversible Ligation of Programmed DNA-Gold Nanoparticle Assemblies

P. K. Harimech, S. R. Gerrard, A. H. El-Sagheer, T. Brown and A. G. Kanaras. J. Am. Chem. Soc. 137 (29), 9242-9245, 2015.

A triazole linkage that mimics the DNA phosphodiester group in living systems

A. H. El-Sagheer and T. Brown. Q. Rev. Biophys 48 (4), 429-436, 2015.

Synthesis and use of universal sequence probes in fluorogenic multi-strand hybridisation complexes for economical nucleic acid testing

D. J. French, J. A. Richardson, R. L. Howard, T. Brown and P. G. Debenham. Mol. Cell. Probes 29 (4), 228-236, 2015.