Tom Brown Group

Dynamics of the 4D genome during in vivo lineage specification and differentiation

A. Marieke Oudelaar, Robert A. Beagrie, Matthew Gosden, Sara de Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf H. El-Sagheer, Jelena M. Telenius, Tom Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs & Jim R. Hughes . Nature Communications 11, 2722, 2020.

Direct Detection and Discrimination of Nucleotide Polymorphisms Using Anthraquinone Labeled DNA Probes

Sarah A. Goodchild, Rachel Gao, Daniel P. Shenton, Alastair J. S. McIntosh, Tom Brown and Philip N. Bartlett*. Frontiers in Chemistry 8, 381, 2020.

Advances and challenges in epigenomic single-cell sequencing applications

Martin Philpott, Adam P. Cribbs, TomBrown Jr, Tom Brown Sr, Udo Oppermann. Current Opinion in Chemical Biology 57, 17-26, 2020.

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

Sven Epple, Cameron Thorpe, Ysobel R. Baker, Afaf H. El-Sagheer, Tom Brown. Chemical Communications 56, 5496-5499, 2020.

Shining Light on CRISPR Gene Editing

Lapatrada Taemaitree and Tom Brown. ACS central science 6 (5), 616-618, 2020.

Molecular flexibility of DNA as a key determinant of RAD51 recruitment

Federico Paoletti, Afaf H El-Sagheer, Jun Allard, Tom Brown, Omer Dushek, Fumiko Esashi. The EMBO Journal 39 (7), 2020.

Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly

Arun Shivalingam, Lapatrada Taemaitree, Afaf H. El-Sagheer, Tom Brown. Angew. Chem. Int. Ed. 59 (28), 11416-11422, 2020.

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

Jack S Hardwick, Marius M Haugland, Afaf H El-Sagheer, Denis Ptchelkine, Frank R Beierlein, Andrew N Lane, Tom Brown, Janet E Lovett, Edward A Anderson. Nucleic Acids Res. 48 (6), 2830-2840, 2020.

Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4

Anders F. Füchtbauer, Moa S. Wranne, Sangamesh Sarangamath, Mattias Bood, Afaf H. El-Sagheer, Tom Brown, Henrik Gradén, Morten Grøtli, L. Marcus Wilhelmsson. ChemPlusChem 85 (2), 319-326, 2020.

DNA Structural Changes Induced by Intermolecular Triple Helix Formation

Ibrahim Sayoh, David A. Rusling, Tom Brown, Keith R. Fox*. ACS Omega 5 (3), 1679-1687, 2020.

Searching for the ideal triazole: Investigating the 1,5-triazole as a charge neutral DNA backbone mimic

Ysobel R. Baker, Diallo Traoré, Przemyslaw Wanat, Agnès Tyburn, Afaf H. El-Sagheer, TomBrown. Tetrahedron 76 (7), 130914, 2020.

Oxidative DNA Cleavage with Clip-Phenanthroline Triplex-Forming Oligonucleotide Hybrids

Alessandro Panattoni, Afaf H. El-Sagheer, Tom Brown, Andrew Kellett, Michal Hocek. ChemBioChem 21, 991-1000, 2020.

Stability of the different arms of a DNA tetrahedron and its interaction with a minor groove ligand

Michael L.J. Carter, David A. Rusling, Steven Gurr, Tom Brown, Keith R. Fox. Biophysical Chemistry 25, 106270, 2020.

Optimised oligonucleotide substrates to assay XPF ERCC1 nuclease activity for the discovery of DNA repair inhibitors

A. M. Thomas, S. Brolih, J. F. McGouran, A. H. El-Sagheer, D. Ptchelkine, M. Jones P. J. McHugh and T. Brown. Chem. Commun. 55 (78), 11671-11674, 2019.

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

William Doherty, Eva-Maria Dürr, Hannah T. Baddock, Sook Y. Lee, Peter J. McHugh, Tom Brown, Mathias O. Senge, Eoin M. Scanlana, Joanna F. McGouran. Organic and Biomolecular Chemistry 17, 8094-8105, 2019.

Radiolabeled oligonucleotides targeting the RNA subunit of telomerase inhibit telomerase and induce DNA damage in telomerase-positive cancer cells

M. R. Jackson, B. M. Bavelaar, P. A. Waghorn, M. R. Gill, A. H. El-Sagheer, T. Brown, M. Tarsounas and K. A. Vallis. Cancer Res. 2019.

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting

P. Klimkowski, S. De Ornellas, D. Singleton, A. H. El-Sagheer and T. Brown. Org. Biomol. Chem. 17, 5943-5950, 2019.

Curtailing their negativity

A. Brown and T. Brown. Nat. Chem. 11 (6), 501-503, 2019.

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications

C. Thorpe, S. Epple, B. Woods, A. H. El-Sagheer and T. Brown. Org. Biomol. Chem. 17, 5341-5348, 2019.

Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices

Angela F. De Fazio, Afaf H. El-Sagheer, Jason S. Kahn, Iris Nandhakumar, Matthew Richard Burton, Tom Brown, Otto L. Muskens, Oleg Gang*, and Antonios G. Kanaras*. ACS Nano 13 (5), 5771-5777, 2019.