Tom Brown Group

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA

P. Kumar, A. H. El-Sagheer, L. Truong and T. Brown. Chem. Commun. 53, 8910-8913, 2017.

The Sedimentation of Colloidal Nanoparticles in Solution and Its Study Using Quantitative Digital Photography

J. Midelet, A. H. El-Sagheer, T. Brown, A. G. Kanaras and M. H. V. Werts. Part. Part. Syst. Char. 2017.

Site-selective immobilization of functionalized DNA origami on nanopatterned Teflon AF

M. Shaali, J. G. Woller, P. G. Johansson, J. K. Hannestad, L. de Battice, N. Aissaoui, T. Brown, A. H. El-Sagheer, S. Kubatkin, S. Lara-Avila, B. Albinsson and A. Jesorka. J. Mater. Chem. C 5, 7637-7643, 2017.

CRISPRi is not strand-specific and redefines the transcriptional landscape

F. S. Howe, A. Russell, A. El-Sagheer, A. Nair, T. Brown and J. Mellor. eLife 6, 29878, 2017.

Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments

H. Wang, Y. Zhang, R. Li, J. Nie, A. H. El-Sagheer, T. Brown, Z. Liu and W. Xiao. Chem. Commun. 53, 8407-8410, 2017.

Towards complete sequence flexibility of nucleic acid base analogue FRET

M. S. Wranne, A. F. Füchtbauer, B. Dumat, M. Bood, A. H. El-Sagheer, T. Brown, H. Gradén, M. Grøtli and L. M. Wilhelmsson. J. Am. Chem. Soc. 139 (27), 9271-9280, 2017.

RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks

U. B. Abdullah, J. F. McGouran, S. Brolih, D. Ptchelkine, A. H. El-Sagheer, T. Brown and P. J. McHugh. EMBO J. 36, 2047-2060, 2017.

5-Formylcytosine does not change the global structure of DNA

J. S. Hardwick, D. Ptchelkine, A. H. El-Sagheer, I. Tear, D. Singleton, S. E. V. Phillips, A. N. Lane and T. Brown. Nat. Struct. Mol. Biol. 24, 544-552, 2017.

Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation

A. Shivalingam, A. E. S. Tyburn, A. H. El-Sagheer and T. Brown. J. Am. Chem. Soc. 139 (4), 1575-1583, 2017.

Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer’s Disease and Prostate Cancer

P. Vilela, A. H. El-Sagheer, T. M. Millar, T. Brown, O. L. Muskens and A. G. Kanaras. ACS Sensors 2 (1), 52-56, 2017.

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA.

Taemaitree, L.; Shivalingam, A.; El-Sagheer, A. H.; Brown, T.. Nature Communications 10 (1), 1610, 2019.

Structure of the ?-globin locus through in vivo erythroid differentiation with extreme spatial and temporal resolution.

Oudelaar, A. M.; Beagrie, R. A.; Gosden, M.; de Ornellas, S.; Georgiades, E.; Kerry, J.; Hidalgo, D.; Carrelha, J.; Shivalingam, A.; El-Sagheer, A. H.; Telenius, J. M.; Brown, T.; Buckle, V. J.; Socolovsky, M.; Higgs, D. R.; Hughes, J. R.. biorvix 763763, 2019.

DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals.

36. Moros, M.; Kyriazi, M.-E.; El-Sagheer, A. H.; Brown, T.; Tortiglione, C.; Kanaras, A. G.. ACS Applied Materials & Interfaces 11 (15), 13905-13911, 2019.

Optimising DNA-Coated Gold Nanoparticles to Enrich Skeletal Stem Cells from Human Bone Marrow Samples.

Lanham, S.; Xavier, M.; Kyriazi, M.; Alexaki, K.; El-Sagheer, A.; Brown, T.; Kanaras, A.; Oreffo, R. O. C.. biorvix 2019.

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Doherty, W.; Dürr, E.-M.; Baddock, H. T.; Lee, S. Y.; McHugh, P. J.; Brown, T.; Senge, M. O.; Scanlan, E. M.; McGouran, J. F.. Organic and Biomolecular Chemistry 17 (35), 8094-8105, 2019.

Light-induced reversible DNA ligation of gold nanoparticle superlattices.

De Fazio, A. F.; El-Sagheer, A. H.; Kahn, J. S.; Nandhakumar, I.; Burton, M. R.; Brown, T.; Muskens, O. L.; Gang, O.; Kanaras, A. G.. ACS Nano 13 (5), 5771-5777, 2019.

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

W. Doherty, E. Dürr, H. T. Baddock, S. Y. L, P. J. McHugh, T. Brown, M. O. Senge, E. M. Scanlana and J. F. McGouran. Org. Biomol. Chem. 2019.

Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

J. Midelet, A. H. El-Sagheer, T. Brown, A. G. Kanaras, A. Debarre and M. H. V. Werts. ChemPhysChem 19 (7), 827-836, 2018.