Jack Hardwick, DPhil student in the Brown group, has won the poster competition at the RSC Chemical Biology Symposium in London in May 2018. This annual symposium showcases state-of-the-art chemical biology and brings together experts in the field to stimulate research collaboration, networking and engagement. Jack’s poster, entitled ‘Structural studies of DNA containing 5-formylcytosine’, highlights some of his research into how epigenetic cytosine modifications affect the structure of DNA.
In a paper published in Nat. Struct. Mol. Biol., we have shown that, contrary to previous observations, 5-formylcytosine does not significantly alter DNA structure
Arun Shivalingam, Agnes Tyburn and Afaf El-Sagheer’s paper Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation, which describes an exciting new amide bond ligation method for DNA that is chemically orthogonal to CuAAC “click” ligation, has been published online in J. Amer. Chem. Soc..