Tom Brown Group

DNA, nanoparticles and photons - new approaches for clinical diagnostics

T. Melvin, L. Dyadshuka, A. Weld, H. Yin, A. Adam, T. Brown, S. Jaiswal, K. Boudakos, D. C. Smith, J. J. Baumberg and F. Booy. International Symposium on Biophotonics, Nanophotonics and Metamaterials, Hangzhou 20-21, 2006.

Triplex staples: DNA double-strand cross-linking at internal and terminal sites using psoralen-containing triplex-forming oligonucleotides

H. Li, V. J. Broughton-Head, G. M. Peng, V. E. C. Powers, M. J. Ovens, K. R. Fox and T. Brown. Bioconjugate Chem. 17 (6), 1561-1567, 2006.

DNA sequence recognition by an imidazole-containing isopropyl-substituted thiazole polyamide (thiazotropsin B)

A. J. Hampshire, H. Khairallah, A. I. Khalaf, A. H. Ebrahimabadi, R. D. Waigh, C. J. Suckling, T. Brown and K. R. Fox. Bioorg. Med. Chem. Lett. 16 (13), 3469-3474, 2006.

HyBeacon probes for rapid DNA sequence detection and allele discrimination

D. J. French, D. G. McDowell, P. Debenham, N. Gale and T. Brown. Methods Mol. Biol. 2006.

Stable recognition of TA interruptions by triplex forming oligonucleotides containing a novel nucleoside

Y. Wang, D. A. Rusling, V. E. C. Powers, O. Lack, S. D. Osborne, K. R. Fox and T. Brown. Biochemistry 44 (15), 5884-5892, 2005.

A new approach for the identification of common point mutations within the dystrophin gene using MLPA

A. Skinner, E. J. Ashton, J. Sillibourne, T. Brown, A. L. Collins and D. J. Bunyan. British Human Genetics Conference, York S100-S100, 2005.

Fluorescent properties of DNA base analogue tC upon incorporation into DNA - negligible influence of neighbouring bases on fluorescence quantum yield

P. Sandin, L. M. Wilhelmsson, P. Lincoln, V. E. C. Powers, T. Brown and B. Albinsson. Nucleic Acids Res. 33 (16), 5019-5025, 2005.

Four base recognition by triplex-forming oligonucleotides at physiological pH

D. A. Rusling, V. E. C. Powers, R. T. Ranasinghe, Y. Wang, S. D. Osborne, T. Brown and K. R. Fox. Nucleic Acids Res. 33 (9), 3025-3032, 2005.

Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex-forming oligonucleotides at physiological pH

D. A. Rusling, L. Le Strat, V. E. C. Powers, V. J. Broughton-Head, J. Booth, O. Lack, T. Brown and K. R. Fox. FEBS Lett. 579 (29), 6616-6620, 2005.

Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d] pyrimidin-2(7H)-one nucleoside analogues

R. T. Ranasinghe, D. A. Rusling, V. E. C. Powers, K. R. Fox and T. Brown. Chem. Commun. 2555-2557, 2005.

Fluorescence based strategies for genetic analysis

R. T. Ranasinghe and T. Brown. Chem. Commun. 5487-5502, 2005.

Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends

P. A. Olsen, M. Randol, L. Luna, T. Brown and S. Krauss. J. Gene Med. 7 (12), 1534-1544, 2005.

Synthesis and evaluation of a new non-fluorescent quencher in fluorogenic oligonucleotide probes for real-time PCR

J. P. May, L. J. Brown, I. van Delft and T. Brown. Org. Biomol. Chem. 3 (14), 2534-2542, 2005.

An extra dimension in nucleic acid sequence recognition

K. R. Fox and T. Brown. Q. Rev. Biophys 38 (4), 311-320, 2005.

Quenching of CdSe quantum dot emission, a new approach for biosensing

L. Dyadyusha, H. Yin, S. Jaiswal, T. Brown, J. J. Baumberg, F. P. Booy and T. Melvin. Chem. Commun. 3201-3203, 2005.

Exceptionally slow kinetics of the intramolecular quadruplex formed by the Oxytricha telomeric repeat

N. M. Brown, P. A. Rachwal, T. Brown and K. R. Fox. Org. Biomol. Chem. 3 (22), 4153-4157, 2005.

Determining the origin of the stabilization of DNA by 5- aminopropynylation of pyrimidines

J. Booth, T. Brown, S. J. Vadhia, O. Lack, W. J. Cummins, J. O. Trent and A. N. Lane. Biochemistry 44 (12), 4710-4719, 2005.

Submicron patterning of DNA oligonucleotides on silicon

H. B. Yin, T. Brown, J. S. Wilkinson, R. W. Eason and T. Melvin. Nucleic Acids Res. 32 (14), e118, 2004.

Chemical modification and micropatterning of Si(100) with oligonucleotides

H. B. Yin, T. Brown, R. Greef, J. S. Wilkinson and T. Melvin. Microelectron. Eng. 73-74, 830-836, 2004.

Photo-patterning of DNA oligonucleotides on silicon surfaces with micron-scale dimensions

H. B. Yin, T. Brown, R. Greef, S. Mailis, R. W. Eason, J. S. Wilkinson and T. Melvin. Conference on Biophotonics New Frontier - From Genome to Proteome, Strasbourg 1-8, 2004.