Tom Brown Group

Potent Triple Helix Stabilization by 5',3'-Modified Triplex-Forming Oligonucleotides

N. Ben Gaied, Z. Y. Zhao, S. R. Gerrard, K. R. Fox and T. Brown. ChemBioChem 10 (11), 1839-1851, 2009.

Binding of 14-3-3 proteins to a single stranded oligodeoxynucleotide aptamer

R. Stevenson, H. C. Baxter, A. Aitken, T. Brown and R. L. Baxter. Bioorg. Chem. 36 (4-6), 215-219, 2008.

Characterization and use of an unprecedentedly bright and structurally non-perturbing fluorescent DNA base analogue

P. Sandin, K. Borjesson, H. Li, J. Martensson, T. Brown, L. M. Wilhelmsson and B. Albinsson. Nucleic Acids Res. 36 (1), 157-167, 2008.

Kinetic studies on the formation of DNA triplexes containing the nucleoside analogue 2'-O-(2-aminoethyl)-5-(3-amino-1-propynyl)uridine

D. A. Rusling, V. J. Broughton-Head, A. Tuck, H. Khairallah, S. D. Osborne, T. Brown and K. R. Fox. Org. Biomol. Chem. 6 (1), 122-129, 2008.

DNA Polymorphism as an Origin of Adenine-Thymine Tract Length-Dependent Threading Intercalation Rate

P. Nordell, F. Westerlund, A. Reymer, A. H. El-Sagheer, T. Brown, B. Norden and P. Lincoln. J. Am. Chem. Soc. 130 (44), 14651-14658, 2008.

SERS-Melting: A New Method for Discriminating Mutations in DNA Sequences

S. Mahajan, J. A. Richardson, T. Brown and P. N. Bartlett. J. Am. Chem. Soc. 130 (46), 15589-15601, 2008.

Rapid and efficient DNA strand cross-linking by click chemistry

P. Kocalka, A. H. El-Sagheer and T. Brown. ChemBioChem 9 (8), 1280-1285, 2008.

Rapid typing of STRs in the human genome by HyBeacon (R) melting

N. Gale, D. J. French, R. L. Howard, D. G. McDowell, P. G. Debenham and T. Brown. Org. Biomol. Chem. 6 (24), 4553-4559, 2008.

Interrogation of short tandem repeats using fluorescent probes and melting curve analysis: A step towards rapid DNA identity screening

D. J. French, R. L. Howard, N. Gale, T. Brown, D. G. McDowell and P. G. Debenham. Forensic Sci. Int. Genet. 2 (4), 333-339, 2008.

Controlled release of Chol-TEG-DNA from nano- and micropatterned SU-8 surfaces by a spreading lipid film

Y. Erkan, K. Halma, I. Czolkos, A. Jesorka, P. Dommersnes, R. Kumar, T. Brown and O. Orwar. Nano Lett. 8 (1), 227-231, 2008.

A very stable cyclic DNA miniduplex with just two base pairs

A. H. El-Sagheer, R. Kumar, S. Findlow, J. M. Werner, A. N. Lane and T. Brown. ChemBioChem 9 (1), 50-52, 2008.

Synthesis, Serum Stability and Cell Uptake of Cyclic and Hairpin Decoy Oligonucleotides for TCF/LEF and GLI Transcription Factors

A. H. El-Sagheer and T. Brown. Int. J. Pept. Res. Ther. 14 (4), 367-372, 2008.

Synthesis of alkyne and azide modified Oligonucleotides and their cyclisation by the CuAAC (Click) Reaction

A. H. El-Sagheer and T. Brown. Curr. Protoc. Nucleic Acid Chem. 2008.

DNA Closed Nanostructures: A Structural and Monte Carlo Simulation Study

F. B. Bombelli, F. Gambinossi, M. Lagi, D. Berti, G. Caminati, T. Brown, F. Sciortino, B. Norden and P. Baglioni. J. Phys. Chem. B 112 (48), 15283-15294, 2008.

Phospholipid membranes decorated by cholesterol-based oligonucleotides as soft hybrid nanostructures

M. Banchelli, F. Betti, D. Berti, G. Caminati, F. B. Bombelli, T. Brown, L. M. Wilhelmsson, B. Norden and P. Baglioni. J. Phys. Chem. B 112 (35), 10942-10952, 2008.

Synthesis of anthraquinone oligonucleotides for triplex stabilization

Z. Y. Zhao, G. M. Peng, J. Michels, K. R. Fox and T. Brown. Nucleosides Nucleotides Nucl. Acids 26 (8-9), 921-925, 2007.

Deuterated water as super solvent for short carbon nanotubes wrapped by DNA

Q. H. Yang, N. Gale, C. J. Oton, H. Li, I. S. Nandhakumar, Z. Y. Tang, T. Brown and W. H. Loh. Carbon 45 (13), 2701-2703, 2007.

A Raman probe for selective wrapping of single-walled carbon nanotubes by DNA

Q. H. Yang, N. Gale, C. J. Oton, F. Li, A. Vaughan, R. Saito, I. S. Nandhakumar, Z. Y. Tang, H. M. Cheng, T. Brown and W. H. Loh. Nanotechnology 18 (40), 1-5, 2007.

Naphthalenyl- and anthracenyl-ethynyl dT analogues as base discriminating fluorescent nucleosides and intramolecular energy transfer donors in oligonucleotide probes

Q. Xiao, R. T. Ranasinghe, A. M. P. Tang and T. Brown. Tetrahedron 63 (17), 3483-3490, 2007.

Addressable high-information-density DNA nanostructures

J. Tumpane, P. Sandin, R. Kumar, V. E. C. Powers, E. P. Lundberg, N. Gale, P. Baglioni, J. M. Lehn, B. Albinsson, P. Lincoln, L. M. Wilhelmsson, T. Brown and B. Norden. Chem. Phys. Lett. 440 (1), 125-129, 2007.