Tom Brown Group

The crystal structure of d(GGGGCCCC) a model for poly (dG) · poly (dC)

M. McCall, T. Brown and O. Kennard. J. Mol. Biol. 183 (3), 385-396, 1985.

Synthesis, Biophysical and Biological Evaluation of Splice-Switching Oligonucleotides with Multiple LNA-Phosphothiotriester Backbones

Dhara, Debashis; Hill, Alyssa; Ramesh, Abinaya; Wood, Matthew; El-Sagheer, Afaf; Brown, Tom.. Journal of the American Chemical Society 146, 29773-29781, 2024.

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA.

Taemaitree, L.; Shivalingam, A.; El-Sagheer, A. H.; Brown, T.. Nature Communications 10 (1), 1610, 2019.

Structure of the ?-globin locus through in vivo erythroid differentiation with extreme spatial and temporal resolution.

Oudelaar, A. M.; Beagrie, R. A.; Gosden, M.; de Ornellas, S.; Georgiades, E.; Kerry, J.; Hidalgo, D.; Carrelha, J.; Shivalingam, A.; El-Sagheer, A. H.; Telenius, J. M.; Brown, T.; Buckle, V. J.; Socolovsky, M.; Higgs, D. R.; Hughes, J. R.. biorvix 763763, 2019.

DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals.

36. Moros, M.; Kyriazi, M.-E.; El-Sagheer, A. H.; Brown, T.; Tortiglione, C.; Kanaras, A. G.. ACS Applied Materials & Interfaces 11 (15), 13905-13911, 2019.

Optimising DNA-Coated Gold Nanoparticles to Enrich Skeletal Stem Cells from Human Bone Marrow Samples.

Lanham, S.; Xavier, M.; Kyriazi, M.; Alexaki, K.; El-Sagheer, A.; Brown, T.; Kanaras, A.; Oreffo, R. O. C.. biorvix 2019.

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.

Doherty, W.; Dürr, E.-M.; Baddock, H. T.; Lee, S. Y.; McHugh, P. J.; Brown, T.; Senge, M. O.; Scanlan, E. M.; McGouran, J. F.. Organic and Biomolecular Chemistry 17 (35), 8094-8105, 2019.

Light-induced reversible DNA ligation of gold nanoparticle superlattices.

De Fazio, A. F.; El-Sagheer, A. H.; Kahn, J. S.; Nandhakumar, I.; Burton, M. R.; Brown, T.; Muskens, O. L.; Gang, O.; Kanaras, A. G.. ACS Nano 13 (5), 5771-5777, 2019.

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

W. Doherty, E. Dürr, H. T. Baddock, S. Y. L, P. J. McHugh, T. Brown, M. O. Senge, E. M. Scanlana and J. F. McGouran. Org. Biomol. Chem. 2019.

Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

J. Midelet, A. H. El-Sagheer, T. Brown, A. G. Kanaras, A. Debarre and M. H. V. Werts. ChemPhysChem 19 (7), 827-836, 2018.

Loosening the DNA wrapping around single-walled carbon nanotubes by increasing the strand length

Q. H. Yang, Q. Wang, N. Gale, C. J. Oton, L. Cui, I. S. Nandhakumar, Z. Zhu, Z. Tang, T. Brown and W. H. Loh. Nanotechnology 20 (19), 195603, 2009.

Thermodynamic Aspects of DNA Nanoconstruct Stability and Design

P. Sandin, J. Tumpane, K. Borjesson, L. M. Wilhelmsson, T. Brown, B. Norden, B. Albinsson and P. Lincoln. J. Phys. Chem. C 113 (15), 5941-5946, 2009.

The stability of triplex DNA is affected by the stability of the underlying duplex

D. A. Rusling, P. A. Rachwal, T. Brown and K. R. Fox. Biophys. Chem. 145 (2-3), 105-110, 2009.

DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine

D. A. Rusling, G. M. Peng, N. Srinivasan, K. R. Fox and T. Brown. Nucleic Acids Res. 37 (4), 1288-1296, 2009.

The Use of an Electroactive Marker as a SERS Label in an E-melting Mutation Discrimination Assay

S. Mahajan, J. A. Richardson, N. Ben Gaied, Z. Y. Zhao, T. Brown and P. N. Bartlett. Electroanalysis 21 (20), 2190-2197, 2009.

Flexible Acoustic Particle Manipulation Device with Integrated Optical Waveguide for Enhanced Microbead Assays

P. Glynne-Jones, R. J. Boltryk, M. Hill, F. Zhang, L. Dong, J. S. Wilkinson, T. Melvin, N. R. Harris and T. Brown. Anal. Sci. 25 (2), 285-291, 2009.

Multi-modal particle manipulator to enhance bead-based bioassays

P. Glynne-Jones, R. J. Boltryk, M. Hill, F. Zhang, L. Dong, J. S. Wilkinson, T. Brown, T. Melvin and N. R. Harris. International Congress on Ultrasonics, Santiago, Chile 3, 269-275, 2009.

Synthesis and Polymerase Chain Reaction Amplification of DNA Strands Containing an Unnatural Triazole Linkage

A. H. El-Sagheer and T. Brown. J. Am. Chem. Soc. 131 (11), 3958-3964, 2009.

Platform for Controlled Supramolecular Nanoassembly

I. Czolkos, J. K. Hannestad, A. Jesorka, R. Kumar, T. Brown, B. Albinsson and O. Orwar. Nano Lett. 9 (6), 2482-2486, 2009.

Structural analysis of the DNA target site and its interaction with Mbp1

A. V. Chernatynskaya, L. Deleeuw, J. O. Trent, T. Brown and A. N. Lane. Org. Biomol. Chem. 7 (23), 4981-4991, 2009.