Structure and dynamics of Triazole-Linked DNA revealed
In a paper published today we reveal the structure of Triazole-Linked DNA: DNA in which one of the phosphodiester linkages is replaced by a triazole. The conformation of the DNA duplex is perturbed only slightly from natural DNA, and the triazole linkage mimics hydrogen-bonding between the DNA phosphate oxygen and polymerase enzymes, providing a basis for the biocompatibility of Triazole-Linked DNA.
Two papers published in Chem. Eur. J. today
Two papers from the Brown group have been published online in the journal Chemistry, a European Journal today: Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained, and 2’-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation.
Congratulations to Dr Lucy Hall
Congratulations to Lucy Hall, who passed her PhD oral examination today. Lucy will remain in the Brown group as a post-doctoral researcher.