Two papers published in Chem. Eur. J. today
Two papers from the Brown group have been published online in the journal Chemistry, a European Journal today: Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained, and 2’-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation.
Congratulations to Dr Lucy Hall
Congratulations to Lucy Hall, who passed her PhD oral examination today. Lucy will remain in the Brown group as a post-doctoral researcher.
New 'reverse click' method of labelling DNA with fluorophores
In a paper entitled Efficient reverse click labeling of azide oligonucleotides with multiple alkynyl Cy-Dyes applied to the synthesis of HyBeacon probes for genetic analysis we describe the labelling of DNA with fluororescent dyes, using click chemistry. Unlike most of applications of click labelling, this ‘reverse’ method uses alkyne-derivatized fluorophores and azide-labeled oligonucleotides.