New paper on triplex-forming oligonucleotides published in Nucleic Acids Research
A paper entitled Secondary binding sites for heavily modified triplex forming oligonucleotides, a collaboration with Prof. Keith Fox, has been published online in Nucleic Acids Research.
Brown group research featured on University of Southampton home page
Prof. Tom Brown’s work on DNA testing for diagnosis, crime scene analysis and personalised medicine has been featured on the front page of the University of Southampton website: www.soton.ac.uk
Structure and dynamics of Triazole-Linked DNA revealed
In a paper published today we reveal the structure of Triazole-Linked DNA: DNA in which one of the phosphodiester linkages is replaced by a triazole. The conformation of the DNA duplex is perturbed only slightly from natural DNA, and the triazole linkage mimics hydrogen-bonding between the DNA phosphate oxygen and polymerase enzymes, providing a basis for the biocompatibility of Triazole-Linked DNA.