Tom Brown Group

Tyrosine-27 of the Specificity Polypeptide of EcoKI Can Be Uv Cross-Linked to a Bromodeoxyuridine-Substituted DNA Target Sequence

A. Chen, L. M. Powell, D. T. F. Dryden, N. E. Murray and T. Brown. Nucleic Acids Res. 23 (7), 1177-1183, 1995.

Detection of PCR products from Mycobacterium avium subspecies Paratuberculosis using oligonucleotides containing multiple 2,4-dinitrophenyl reporter groups.

K. Stevenson, C. A. Walker, J. Grzybowski and T. Brown. Biomed. Pept. Proteins Nucleic Acids 1 (1), 17-20, 1994.

Synthesis and Antibody-Mediated Detection of 2,4-Dinitrophenyl (DNP) Labeled Oligonucleotides

M. V. Rao, G. Duckworth, A. Davison, J. Maclean, J. Grzybowski and T. Brown. Clin. Chem. 40 (12), 2335-2336, 1994.

Crystal-Structure of a DNA Duplex Containing 8-Hydroxydeoxyguanine-Adenine Base-Pairs

K. E. McAuley-Hecht, G. A. Leonard, N. J. Gibson, J. B. Thomson, W. P. Watson, W. N. Hunter and T. Brown. Biochemistry 33 (34), 10266-10270, 1994.

Guanine-1,N-6-Ethenoadenine Base-Pairs in the Crystal-Structure of d(CGCGAATT(edA)GCG)

G. A. Leonard, K. E. McAuley-Hecht, N. J. Gibson, T. Brown, W. P. Watson and W. N. Hunter. Biochemistry 33 (16), 4755-4761, 1994.

Crystal and Molecular-Structure of r(CGCGAAUUGGCG) - an RNA Duplex Containing two G(anti).A(anti) Base-Pairs

G. A. Leonard, K. E. McAuley-Hecht, S. Ebel, D. M. Lough, T. Brown and W. N. Hunter. Structure 2 (6), 483-494, 1994.

Studies of the Structure and Stability of Base-Pair Mismatches, Base-Pairs Involving Modified Bases, and DNA-Drug Complexes

G. A. Leonard, W. N. Hunter and T. Brown. J. Chem. Crystallogr. 24 (1), 5-15, 1994.

Properties of Multiple G.A Mismatches in Stable Oligonucleotide Duplexes

A. N. Lane, S. Ebel and T. Brown. Eur. J. Biochem. 220 (3), 717-727, 1994.

Using Linkers to Investigate the Spatial Separation of the Conserved Nucleotides A(9) and G(12) in the Hammerhead Ribozyme

P. Hendry, M. J. Moghaddam, M. J. McCall, P. A. Jennings, S. Ebel and T. Brown. Biochim. Biophys. Acta Gene Struct. Expression 1219 (2), 405-412, 1994.

The Stability of Duplex DNA Containing 3,N-4-Etheno-2'-Deoxycytidine (edC) - a UV Melting and High-Resolution H-1-NMR Study

N. J. Gibson, J. A. Parkinson, T. Barlow, W. P. Watson and T. Brown. J. Chem. Soc., Chem. Commun. 2241-2242, 1994.

Thermodynamic Stability and Solution Conformation of Tandem G.A Mismatches in RNA and RNA.DNA Hybrid Duplexes

S. Ebel, T. Brown and A. N. Lane. Eur. J. Biochem. 220 (3), 703-715, 1994.

Synthesis and antibody-mediated detection of 2,4-dinitrophenyl (DNP) labelled oligonucleotides

A. Davison, G. Duckworth, M. V. Rao, J. McClean, J. Grzybowski, P. Potier, T. Brown and H. Cubie. 11th International Round Table on Nucleosides, Nucleotides and Their Biological Applications, Leuven, Belgium 1049-1052, 1994.

Branched Poly-Labeled Oligonucleotides - Enhanced Specificity of Fork-Shaped Biotinylated Oligoribonucleotides for Antisense Affinity Selection

S. Teigelkamp, S. Ebel, D. W. Will, T. Brown and J. D. Beggs. Nucleic Acids Res. 21 (19), 4651-4652, 1993.

Thermodynamic Stability and Drug-Binding Properties of Oligodeoxyribonucleotide Duplexes Containing 3-Deazaadenine - Thymine Base-Pairs

C. Lever, X. Li, R. Cosstick, S. Ebel and T. Brown. Nucleic Acids Res. 21 (8), 1743-1746, 1993.

Anthracycline DNA Interactions at Unfavorable Base-Pair Triplet-Binding Sites - Structures of d(CGGCCG) Daunomycin and d(TGGCCA) Adriamycin Complexes

G. A. Leonard, T. W. Hambley, K. E. McAuley-Hecht, T. Brown and W. N. Hunter. Acta Crystallogr. Sect. D. Biol. Crystallogr. 49, 458-467, 1993.

NMR Assignments and Solution Conformation of the DNA.RNA Hybrid Duplex d(GTGAACTT).r(AAGUUCAC)

A. N. Lane, S. Ebel and T. Brown. Eur. J. Biochem. 215 (2), 297-306, 1993.

Synthesis and Antibody-Mediated Detection of Oligonucleotides Containing Multiple 2,4-Dinitrophenyl Reporter Groups

J. Grzybowski, D. W. Will, R. E. Randall, C. A. Smith and T. Brown. Nucleic Acids Res. 21 (8), 1705-1712, 1993.

The Structure of an Idarubicin-d(TGATCA) Complex at High- Resolution

B. Gallois, B. L. Destaintot, T. Brown and W. N. Hunter. Acta Crystallogr. Sect. D. Biol. Crystallogr. 49, 311-317, 1993.

Mismatches in DNA Duplexes

T. Brown, W. N. Hunter and G. A. Leonard. Chem. Br. 29 (6), 484-&, 1993.

Attachment of Vitamin-E Derivatives to Oligonucleotides During Solid-Phase Synthesis

D. W. Will and T. Brown. Tetrahedron Lett. 33 (19), 2729-2732, 1992.