Dr Nicolo Fantoni

Dr Nicolo Fantoni

Post-doctoral researcher (2019-2022)

Nicolò Zuin Fantoni was born in Padova, Italy.He studied chemistry at the University of Padova, receiving his MSc degree in 2014 for work in bioinorganic chemistry. In 2015, he joined the Kellett group at Dublin City University (DCU) as an Marie Curie PhD student within the ClickGene ITN project. Here, he worked on developing new copper polypyridyl complexes as stabilized artificial metallonucleases (AMN) and linking them to triplex-forming oligonucleotides by CuAAC and SPAAC reactions. In 2019 he joined the Brown group at the University of Oxford, where he is working on the biocompatible triazole linkage.

4 Papers

Development of Gene-Targeted Polypyridyl Triplex-Forming Oligonucleotide Hybrids

Nicolò Zuin Fantoni, Bríonna McGorman, Zara Molphy, Daniel Singleton, Sarah Walsh, Afaf H. El-Sagheer, Vickie McKee, Tom Brown, Andrew Kellett. ChemBioChem 21 (24), 3563-3574, 2020.

DNA-Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology

Nicolò Zuin Fantoni, Tom Brown, Andrew Kellett. ChemBioChem 22 (13), 2184-2205, 2021.

A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

Nicolò Zuin Fantoni, Afaf H. El-Sagheer, and Tom Brown*. Chemical Reviews 121 (12), 7122-7154, 2021.

Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications

Brionna McGorman, Nicolo Zuin Fantoni , Sinead O’Carroll , Anna Ziemele, Afaf H. El-Sagheer, Tom Brown and Andrew Kellett. Nucleic Acids Research 50, 5467-5487, 2022.