Dr Montse Shelbourne

Dr Montse Shelbourne

Graduate student (2008-2012)

Montse did her undergraduate and masters degrees at the University of Southampton (2004-2008). During her masters she worked for 6 months with ATDBio on the subject of chemical synthesis and on studies on the effect of modified monomers on the thermal stability of triplex-forming oligonucleotides. Montse started her PhD in the Brown group in October 2008. She worked on various projects: a triplex approach to gene inhibition via the synthesis of modified monomers for the stabilisation of DNA triplexes; the delivery of oligonucleotides into cells; and methods for copper-free click chemistry.

6 Papers

Six-Colour HyBeacon Probes for Multiplex Genetic Analysis

J. A. Richardson, M. Gerowska, M. Shelbourne, D. J. French and T. Brown. ChemBioChem 11 (18), 2530-2533, 2010.

Fast Copper-Free Click DNA Ligation by the Ring Strain Promoted Alkyne-Azide Cycloaddition Reaction

M. Shelbourne, X. Chen, T. Brown and A. H. El-Sagheer. Chem. Commun. 47, 6257-6259, 2011.

Efficient reverse click labeling of azide oligonucleotides with multiple alkynyl Cy-Dyes applied to the synthesis of HyBeacon probes for genetic analysis

M. Gerowska, L. M. Hall, J. A. Richardson, M. Shelbourne and T. Brown. Tetrahedron 68 (3), 857-864, 2012.

2'-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation

C. Lou, M. Shelbourne, K. R. Fox and T. Brown. Chem. Eur. J. 17 (52), 14851-14856, 2011.

Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry

M. Shelbourne, T. Brown Jr, A. H. El-Sagheer and T. Brown. Chem. Commun. 2012.

A New Modular Approach to Nanoassembly: Stable and Addressable DNA Nanoconstructs via Orthogonal Click Chemistries

S. R. Gerrard, C. Hardiman, M. Shelbourne, I. Nandhakumar, B. Norden and T. Brown. ACS Nano 6 (10), 9221-9228, 2012.