Sven Epple

Sven Epple

Graduate student (2018-2021)

Originally from the south of Germany, Sven obtained his Master of Science in Life Science from the University of Konstanz. During his studies, Sven conducted a 3-month internship at the King Mongkut’s University of Technology Thonburi in Bangkok, Thailand, in the field of medicinal chemistry. For his master’s project, Sven spent 6 months in Prof. Gunda I. Georg’s laboratory at the University of Minnesota, USA, researching novel bromodomain inhibitors for male contraception. His academic interests are organic synthesis, drug design/development and chemical biology. Currently, Sven is investigating oligonucleotides with different backbone modifications for various applications in therapeutics and diagnostics. When not working, Sven likes to go swimming or running.

4 Papers

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

Sven Epple, Cameron Thorpe, Ysobel R. Baker, Afaf H. El-Sagheer, Tom Brown. Chemical Communications 56, 5496-5499, 2020.

Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology

Sven Epple, Afaf H. El-Sagheer, Tom Brown. Energing topics in life science 5 (5), 691-697, 2021.

A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility

Sven Epple, Aman Modi, Ysobel R. Baker, Ewa Wegrzyn, Diallo Traoré, Przemyslaw Wanat, Agnes E. S. Tyburn, Arun Shivalingam, Lapatrada Taemaitree, Afaf H. El-Sagheer, and Tom Brown*. Journal of the American Chemical Society 143 (39), 16293-16301, 2021.

An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides

Ysobel Baker, Cameron Thorpe, Jinfeng Chen, Laura Poller, Lina Cox, Pawan Kumar, Wooi Fang Lim, Lillian Lie, Graham McClorey, Sven Epple, Daniel Singleton, Michael McDonough, Jack Hardwick, Kirsten Christensen, Matthew Wood, James Hall, Afaf El-Sagheer, Tom Brown. Nature Communications 13 (1), 1-11, 2022.