Dr Nouha Ben Gaied

Dr Nouha Ben Gaied

Post-doctoral researcher (2007-2011)

Nouha prepared her PhD at the university of Louis Pasteur (Strasbourg I, 2006) in organic chemistry under the supervision of Pr. Alain Burger. She was involved in two main projects; the preparation of fluorescent nucleoside probes as alternative to the 2AP as well as modified nucleosides analogues with antiviral properties targeting the Reverse Transcriptase of HIV-1. She then moved in 2007 to Southampton university in Tom Brown’s group as a research scientist in the nucleic acid field. She was involved in an EU funded project aiming at preparing new molecules to increase the stability of Triplex Forming Oligonucleotide (TFO) and used them as new tools for genetic and forensic science purposes.

5 Papers

Potent Triple Helix Stabilization by 5',3'-Modified Triplex-Forming Oligonucleotides

N. Ben Gaied, Z. Y. Zhao, S. R. Gerrard, K. R. Fox and T. Brown. ChemBioChem 10 (11), 1839-1851, 2009.

The Use of an Electroactive Marker as a SERS Label in an E-melting Mutation Discrimination Assay

S. Mahajan, J. A. Richardson, N. Ben Gaied, Z. Y. Zhao, T. Brown and P. N. Bartlett. Electroanalysis 21 (20), 2190-2197, 2009.

End-capped HyBeacon probes for the analysis of human genetic polymorphisms related to warfarin metabolism

N. Ben Gaied, J. A. Richardson, D. G. Singleton, Z. Y. Zhao, D. French and T. Brown. Org. Biomol. Chem. 8 (12), 2728-2734, 2010.

2’-Substituted 2-Amino-3-Methylpyridine Ribonucleosides in Triplex-Forming Oligonucleotides: Triplex Stability is Determined by Chemical Environment

C. Lou, Q. Xiao, R. R. Tailor, N. Ben Gaied, N. Gale, M. E. Light, K. R. Fox and T. Brown. Med. Chem. Comm. 2, 550-558, 2011.

Quadracyclic Adenine: A Non-perturbing Fluorescent Adenine Analogue

A. Dierckx, F. Miannay, N. Ben Gaied, S. Preus, M. Bjorck, T. Brown and L. M. Wilhelmsson. Chem. Eur. J. 18 (19), 5987-5997, 2012.