Dr Lapatrada Taemaitree

Dr Lapatrada Taemaitree

Post-doctoral researcher (2014-)

Lapatrada completed her undergraduate degree in Molecular and Cellular Biochemistry at University of Oxford (2014). Her project in the final year was the study of the FtsK gamma subdomain as a smart controller of DNA translocase activity under the supervision of Prof David Sherratt. She then joined the Brown group as a DPhil student, where she focussed on genome editing and diagnostic applications using chemically modified CRISPR-Cas guide RNAs. After successfully defending her thesis (January 2019), she stayed in the group as a post-doctoral researcher with the aim of addressing the exciting findings she made and developing further CRISPR and diagnostic applications.

6 Papers

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA

L. Taemaitree, A. Shivalingam, A. H. El-Sagheer and T. Brown. Nat. Commun. 10, 2019.

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA.

Taemaitree, L.; Shivalingam, A.; El-Sagheer, A. H.; Brown, T.. Nature Communications 10 (1), 1610, 2019.

“Split-and-Click” sgRNA

Lapatrada Taemaitree, Arun Shivalingam, Afaf H. El-Sagheer, Tom Brown. Methods in molecular biology 2162, 61-78, 2019.

Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly

Arun Shivalingam, Lapatrada Taemaitree, Afaf H. El-Sagheer, Tom Brown. Angew. Chem. Int. Ed. 59 (28), 11416-11422, 2020.

Shining Light on CRISPR Gene Editing

Lapatrada Taemaitree and Tom Brown. ACS central science 6 (5), 616-618, 2020.

A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility

Sven Epple, Aman Modi, Ysobel R. Baker, Ewa Wegrzyn, Diallo Traoré, Przemyslaw Wanat, Agnes E. S. Tyburn, Arun Shivalingam, Lapatrada Taemaitree, Afaf H. El-Sagheer, and Tom Brown*. Journal of the American Chemical Society 143 (39), 16293-16301, 2021.