Dr Cheng Jin

Dr Cheng Jin

Post-doctoral researcher (2019-2022)

Cheng received his PhD in chemistry in 2018 at the Hunan University, China, under the supervision of Prof. Weihong Tan. His doctor thesis focused on the development of oligonucleotide amphiphiles for biomedical applications. Cheng joined in Tom’s group in 2019 and engaging in projects of cathepsin B-triggered therapeutic oligonucleotides.

3 Papers

Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers

Cheng Jin, A. H. EI-Sagheer, Siqi Li, Katherine A. Vallis, Weihong Tan, Tom Brown. Angew. Chem. Int. Ed. e202114016 1, 2022.

A new phosphoramidite enables orthogonal double labelling to form combination oligonucleotide probes

Chunsen Bai, Piotr Klimkowski, Cheng Jin, Jagannath Kuchlyan, Afaf H. El-Sagheer* and Tom Brown*. Org. Biomol. Chem. 20, 8618-8622, 2022.

Modular and Automated Synthesis of Oligonucleotide-Small Molecule Conjugates for Cathepsin B Mediated Traceless Release of Payloads

Cheng Jin, Siqi Li, Katherine A. Vallis, Afaf H. El-Sagheer and Tom Brown. RSC Chemical Biology