Prof. Laurence Pearl

Prof. Laurence Pearl

Prof. Pearl is Professor of Protein Crystallography at the Institute of Cancer Research, London.

7 Papers

Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct

T. E. Barrett, R. Savva, T. Barlow, T. Brown, J. Jiricny and L. H. Pearl. Nat. Struct. Biol. 5 (8), 697-701, 1998.

Crystal structure of a G : T/U mismatch-specific DNA glycosylase: Mismatch recognition by complementary-strand interactions

T. E. Barrett, R. Savva, G. Panayotou, T. Barlow, T. Brown, J. Jiricny and L. H. Pearl. Cell 92 (1), 117-129, 1998.

Direct measurement of the substrate preference of uracil-DNA glycosylase

G. Panayotou, T. Brown, T. Barlow, L. H. Pearl and R. Savva. J. Biol. Chem. 273 (1), 45-50, 1998.

Crystal structure of an octameric RuvA-Holliday junction complex

S. M. Roe, T. Barlow, T. Brown, M. Oram, A. Keeley, I. R. Tsaneva and L. H. Pearl. Mol. Cell 2 (3), 361-372, 1998.

Crystal structure of a thwarted mismatch glycosylase DNA repair complex

T. E. Barrett, O. D. Scharer, R. Savva, T. Brown, J. Jiricny, G. L. Verdine and L. H. Pearl. EMBO J. 18 (23), 6599-6609, 1999.

The mechanism of DNA repair by uracil-DNA glycosylase: Studies using nucleotide analogues

A. Rosler, G. Panayotou, D. P. Hornby, T. Barlow, T. Brown, L. H. Pearl, R. Savva and G. M. Blackburn. Nucleosides Nucleotides Nucl. Acids 19 (10-12), 1505-1516, 2000.

Crystal structure of the Escherichia coli DCM very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix

K. A. Bunting, S. M. Roe, A. Headley, T. Brown, R. Savva and L. H. Pearl. Nucleic Acids Res. 31 (6), 1633-1639, 2003.