Dr Ysobel Baker

Dr Ysobel Baker

Post-doctoral researcher (2015-2021)

Ysobel obtained her masters degree in Chemistry from the University of Southampton before moving to the University of Cambridge for her PhD studies, working at the chemistry/biology interface under the supervision of Prof. David Spring. She joined the Brown group in October 2015 investigating oligonucleotide functionalised nanoparticles with diagnostic and therapeutic applications and developing new artificual DNA backbone likkages. Yssy recently moved to the Nucleic Acid Therapeutics Accelerator MRC Unit at Harwell.

10 Papers

Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

P. Kumar, L. Truong Y. R. Baker, A. H. El-Sagheer and T. Brown. ACS Omega 3 (6), 6976-6987, 2018.

Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size

Y. R. Baker, J. Chen, J. Brown, A. H. El-Sagheer, P. Wiseman, E. Johnson, P. Goddard and T. Brown. Nucleic Acids Res. 46 (15), 7495-7505, 2018.

Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation

J. Chen, Y. R. Baker, A. Brown, A. H. El-Sagheer and T. Brown. Chem. Sci. 9, 8110-8120, 2018.

Searching for the ideal triazole: Investigating the 1,5-triazole as a charge neutral DNA backbone mimic

Ysobel R. Baker, Diallo Traoré, Przemyslaw Wanat, Agnès Tyburn, Afaf H. El-Sagheer, TomBrown. Tetrahedron 76 (7), 130914, 2020.

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

Sven Epple, Cameron Thorpe, Ysobel R. Baker, Afaf H. El-Sagheer, Tom Brown. Chemical Communications 56, 5496-5499, 2020.

Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification

Ysobel R Baker, Liyiwen Yuan, Jinfeng Chen, Roman Belle, Robert Carlisle, Afaf H El-Sagheer, Tom Brown. Nucleic Acids Res. 49 (16), 9042-9052, 2021.

A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility

Sven Epple, Aman Modi, Ysobel R. Baker, Ewa Wegrzyn, Diallo Traoré, Przemyslaw Wanat, Agnes E. S. Tyburn, Arun Shivalingam, Lapatrada Taemaitree, Afaf H. El-Sagheer, and Tom Brown*. Journal of the American Chemical Society 143 (39), 16293-16301, 2021.

Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly

Angela F. De Fazio, Doxi Misatziou, Ysobel R. Baker, Otto L. Muskens, Tom Brown and Antonios G. Kanaras. Chemical Society Reviews 50, 13410-13440, 2021.

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Anna Dysko, Ysobel R. Baker, Graham McClorey, Matthew J. A. Wood, Sabine Fenner, Glynn Williams, Afaf El-Sagheer and Tom Brown. RSC Chemical Biology 3, 765-772, 2022.

Oligonucleotide analogues with locked-amide linkages have therapeutic potential

Ysobel Baker, Cameron Thorpe, Jinfeng Chen, Laura Poller, Lina Cox, Pawan Kumar, Wooi Fang Lim, Lillian Lie, Graham McClorey, Sven Epple, Daniel Singleton, Michael McDonough, Jack Hardwick, Kirsten Christensen, Matthew Wood, James Hall, Afaf El-Sagheer, Tom Brown. Research Square 0, 0, 2022.