Prof. Keith Fox

Prof. Keith Fox

50 Papers

Coralyne has a preference for intercalation between TA.T triplets in intramolecular DNA triple helices

A. A. Moraru-Allen, S. Cassidy, J. L. A. Alvarez, K. R. Fox, T. Brown and A. N. Lane. Nucleic Acids Res. 25 (10), 1890-1896, 1997.

5-(1-propargylamino)-2'-deoxyuridine (U-P): a novel thymidine analogue for generating DNA triplexes with increased stability

J. Bijapur, M. D. Keppler, S. Bergqvist, T. Brown and K. R. Fox. Nucleic Acids Res. 27 (8), 1802-1809, 1999.

DNA triple helix formation at target sites containing several pyrimidine interruptions: Stabilization by protonated cytosine or 5-(1-propargylamino)dU

D. M. Gowers, J. Bijapur, T. Brown and K. R. Fox. Biochemistry 38 (41), 13747-13758, 1999.

DNA triple helix stabilisation by covalent attachment of a triplex-specific ligand

M. D. Keppler, C. M. McKeen, O. Zegrocka, L. Strekowski, T. Brown and K. R. Fox. Biochim. Biophys. Acta Gene Struct. Expression 1447 (2-3), 137-145, 1999.

Recognition of GT mismatches by Vsr mismatch endonuclease

K. R. Fox, S. L. Allinson, H. Sahagun-Krause and T. Brown. Nucleic Acids Res. 28 (13), 2535-2540, 2000.

Synthesis of a novel bis-amino-modified thymidine monomer for use in DNA triplex stabilisation

M. Sollogoub, B. Dominguez, K. R. Fox and T. Brown. Phys. Chem. Chem. Phys. 2 (23), 2315-2316, 2000.

Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches

J. Brown, T. Brown and K. R. Fox. Biochem. J 354, 627-633, 2001.

High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler

R. A. J. Darby, M. Sollogoub, C. M. McKeen, L. Brown, A. Risitano, N. Brown, C. Barton, T. Brown and K. R. Fox. Nucleic Acids Res. 30 (9), e39, 2002.

Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U

M. Sollogoub, R. A. J. Darby, B. Cuenoud, T. Brown and K. R. Fox. Biochemistry 41 (23), 7224-7231, 2002.

First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine

M. Sollogoub, K. R. Fox, V. E. C. Powers and T. Brown. Tetrahedron Lett. 43 (17), 3121-3123, 2002.

Cleavage of fragments containing DNA mismatches by enzymic and chemical probes

J. Brown, T. Brown and K. R. Fox. Biochem. J 371, 697-708, 2003.

Thermodynamic and kinetic stability of intermolecular triple helices containing different proportions of C+.GC and T.AT triplets

P. L. James, T. Brown and K. R. Fox. Nucleic Acids Res. 31 (19), 5598-5606, 2003.

DNA sequence specificity of triplex-binding ligands

M. D. Keppler, P. L. James, S. Neidle, T. Brown and K. R. Fox. Eur. J. Biochem. 270 (24), 4982-4992, 2003.

Effects of a hairpin polyamide on DNA melting: comparison with distamycin and Hoechst 33258

P. L. James, L. Le Strat, U. Ellervik, C. Bratwall, B. Norden, T. Brown and K. R. Fox. Biophys. Chem. 111 (3), 205-212, 2004.

DNA sequence recognition by an isopropyl substituted thiazole polyamide

P. L. James, E. E. Merkina, A. I. Khalaf, C. J. Suckling, R. D. Waigh, T. Brown and K. R. Fox. Nucleic Acids Res. 32 (11), 3410-3417, 2004.

Selectivity and affinity of triplex-forming oligonucleotides containing 2'-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine for recognizing AT base pairs in duplex DNA

S. D. Osborne, V. E. C. Powers, D. A. Rusling, O. Lack, K. R. Fox and T. Brown. Nucleic Acids Res. 32 (15), 4439-4447, 2004.

Exceptionally slow kinetics of the intramolecular quadruplex formed by the Oxytricha telomeric repeat

N. M. Brown, P. A. Rachwal, T. Brown and K. R. Fox. Org. Biomol. Chem. 3 (22), 4153-4157, 2005.

An extra dimension in nucleic acid sequence recognition

K. R. Fox and T. Brown. Q. Rev. Biophys 38 (4), 311-320, 2005.

Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d] pyrimidin-2(7H)-one nucleoside analogues

R. T. Ranasinghe, D. A. Rusling, V. E. C. Powers, K. R. Fox and T. Brown. Chem. Commun. 2555-2557, 2005.

Combining nucleoside analogues to achieve recognition of oligopurine tracts by triplex-forming oligonucleotides at physiological pH

D. A. Rusling, L. Le Strat, V. E. C. Powers, V. J. Broughton-Head, J. Booth, O. Lack, T. Brown and K. R. Fox. FEBS Lett. 579 (29), 6616-6620, 2005.

Four base recognition by triplex-forming oligonucleotides at physiological pH

D. A. Rusling, V. E. C. Powers, R. T. Ranasinghe, Y. Wang, S. D. Osborne, T. Brown and K. R. Fox. Nucleic Acids Res. 33 (9), 3025-3032, 2005.

Stable recognition of TA interruptions by triplex forming oligonucleotides containing a novel nucleoside

Y. Wang, D. A. Rusling, V. E. C. Powers, O. Lack, S. D. Osborne, K. R. Fox and T. Brown. Biochemistry 44 (15), 5884-5892, 2005.

DNA sequence recognition by an imidazole-containing isopropyl-substituted thiazole polyamide (thiazotropsin B)

A. J. Hampshire, H. Khairallah, A. I. Khalaf, A. H. Ebrahimabadi, R. D. Waigh, C. J. Suckling, T. Brown and K. R. Fox. Bioorg. Med. Chem. Lett. 16 (13), 3469-3474, 2006.

Triplex staples: DNA double-strand cross-linking at internal and terminal sites using psoralen-containing triplex-forming oligonucleotides

H. Li, V. J. Broughton-Head, G. M. Peng, V. E. C. Powers, M. J. Ovens, K. R. Fox and T. Brown. Bioconjugate Chem. 17 (6), 1561-1567, 2006.

DNA triple-helix formation at target sites containing duplex mismatches

D. A. Rusling, T. Brown and K. R. Fox. Biophys. Chem. 123 (2-3), 134-140, 2006.

2'-O-dimethylaminoethoxyuridine and 5-dimethylaminopropargyl deoxyuridine for at base pair recognition in triple helices

L. Brennan, G. M. Peng, N. Srinivasan, K. R. Fox and T. Brown. Nucleosides Nucleotides Nucl. Acids 26 (10-12), 1283-1286, 2007.

CG base pair recognition within DNA triple helices using N-methyl-3H-pyrrolo 2,3-d pyrimidin-2(7H)-one nucleoside analogues

S. R. Gerrard, N. Srinivasan, K. R. Fox and T. Brown. Nucleosides Nucleotides Nucl. Acids 26 (10-12), 1363-1367, 2007.

Photoinduced crosslinking of double-helical DNA by psoralen covalently linked to a triple helix-forming oligonucleotide under near-physiological conditions

H. Li, V. J. Broughton-Head, K. R. Fox and T. Brown. Nucleosides Nucleotides Nucl. Acids 26 (8-9), 1005-1009, 2007.

Sequence effects of single base loops in intramolecular quadruplex DNA

P. A. Rachwal, T. Brown and K. R. Fox. FEBS Lett. 581 (8), 1657-1660, 2007.

Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes

P. A. Rachwal, T. Brown and K. R. Fox. Biochemistry 46 (11), 3036-3044, 2007.

Intramolecular DNA quadruplexes with different arrangements of short and long loops

P. A. Rachwal, I. S. Findlow, J. M. Werner, T. Brown and K. R. Fox. Nucleic Acids Res. 35 (12), 4214-4222, 2007.

Synthesis of anthraquinone oligonucleotides for triplex stabilization

Z. Y. Zhao, G. M. Peng, J. Michels, K. R. Fox and T. Brown. Nucleosides Nucleotides Nucl. Acids 26 (8-9), 921-925, 2007.

Kinetic studies on the formation of DNA triplexes containing the nucleoside analogue 2'-O-(2-aminoethyl)-5-(3-amino-1-propynyl)uridine

D. A. Rusling, V. J. Broughton-Head, A. Tuck, H. Khairallah, S. D. Osborne, T. Brown and K. R. Fox. Org. Biomol. Chem. 6 (1), 122-129, 2008.

Potent Triple Helix Stabilization by 5',3'-Modified Triplex-Forming Oligonucleotides

N. Ben Gaied, Z. Y. Zhao, S. R. Gerrard, K. R. Fox and T. Brown. ChemBioChem 10 (11), 1839-1851, 2009.

DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine

D. A. Rusling, G. M. Peng, N. Srinivasan, K. R. Fox and T. Brown. Nucleic Acids Res. 37 (4), 1288-1296, 2009.

The stability of triplex DNA is affected by the stability of the underlying duplex

D. A. Rusling, P. A. Rachwal, T. Brown and K. R. Fox. Biophys. Chem. 145 (2-3), 105-110, 2009.

Synthesis and properties of triplex-forming oligonucleotides containing 2'-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine

C. Lou, Q. Xiao, L. Brennan, M. E. Light, N. Vergara-Irigaray, E. M. Atkinson, L. M. Holden-Dye, K. R. Fox and T. Brown. Bioorg. Med. Chem. 18 (17), 6389-6397, 2010.

CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides

S. R. Gerrard, M. M. Edrees, I. Bouamaied, K. R. Fox and T. Brown. Org. Biomol. Chem. 8 (22), 5087-5096, 2010.

2’-Substituted 2-Amino-3-Methylpyridine Ribonucleosides in Triplex-Forming Oligonucleotides: Triplex Stability is Determined by Chemical Environment

C. Lou, Q. Xiao, R. R. Tailor, N. Ben Gaied, N. Gale, M. E. Light, K. R. Fox and T. Brown. Med. Chem. Comm. 2, 550-558, 2011.

Formation of stable DNA triplexes

K. R. Fox and T. Brown. Biochem. Soc. Trans. 39 (2), 629-634, 2011.

2'-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation

C. Lou, M. Shelbourne, K. R. Fox and T. Brown. Chem. Eur. J. 17 (52), 14851-14856, 2011.

Towards the Targeted Modulation of Gene Expression by Modified Triplex-Forming Oligonucleotides

D. A. Rusling, V. J. Broughton-Head, T. Brown and K. R. Fox. Curr. Chem. Biol. 2, 1-10, 2008.

Stable DNA triple helix formation

K. R. Fox, A. S. Cardew, N. Vergara and T. Brown. Nucleic Acids Sym. Ser. 53 (1), 71, 2009.

Secondary binding sites for heavily modified triplex forming oligonucleotides

A. S. Cardew, T. Brown and K. R. Fox. Nucleic Acids Res. 40 (8), 3753-3762, 2012.

Triplex-Directed Recognition of a DNA Nanostructure Assembled by Crossover Strand Exchange

D. A. Rusling, I. S. Nandhakumar, T. Brown and K. R. Fox. ACS Nano 6 (4), 3604-3613, 2012.

Triplex-Directed Covalent Cross-Linking of a DNA Nanostructure

D. A. Rusling, I. Nandhakumar, T. Brown and K. R. Fox. Chem. Commun. 48, 9592-9594, 2012.

Functionalizing Designer DNA Crystals with a Triple-Helical Veneer

D. A. Rusling, A. R. Chandrasekaran, Y. P. Ohayon, T. Brown, K. R. Fox, R. Sha, C. Mao, N. C. Seeman. Angew. Chem. Int. Ed. 53 (15), 3979-3982, 2014.

A Mutant of Uracil DNA Glycosylase That Distinguishes between Cytosine and 5-Methylcytosine

S. T. Kimber, T. Brown and K. R. Fox. PLOS ONE 2014.

The effect of sequence context on the activity of cytosine DNA glycosylases

S. T. Kimber, T. Brown and K. R. Fox. Mol. Biosyst. 106, 353-358, 2015.

Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking

H. O. Abdallah, Y. P. Ohayon, A. R. Chandrasekaran, R. Sha, K. R. Fox, T. Brown, D. A. Rusling, C. Maoe and N. C. Seeman. Chem. Commun. 2016.